PURPOSE: We retrospectively assessed post-EST complications and examined whether combination therapy comprising endoscopic biliary drainage (EBD) plus endoscopic sphincterotomy (EST) as the initial treatment is safe in patients with acute cholangitis due to choledocholithiasis. METHODS: Among the 363 consecutive patients with acute cholangitis due to choledocholithiasis who were treated in our hospital between December 1992 and December 2006, the subjects comprised 127 patients with moderate acute cholangitis for whom EBD and EST were carried out. Factors influencing risk factors for post-EST pancreatitis, hemorrhage and hospitalization were determined by multivariate analysis. RESULTS: Multivariate analysis revealed that only precut sphincterotomy (PST) was a significant risk factor for post-EST pancreatitis, and the incidence of pancreatitis in patients who underwent PST was significantly higher than that in those who did not (P = 0.041). Only age was a significant risk factor for post-EST hemorrhage, and younger patients were likely to experience hemorrhage after EST (P = 0.021). Total bilirubin and the timing of EST were significant factors associated with hospitalization. Hospitalization in patients who underwent EBD plus EST as the initial treatment (emergency EST) was significantly shorter than that in those who palliatively underwent EST after EBD (elective EST; 11.8 vs. 16.2 days, P = 0.001). CONCLUSIONS: Combination therapy comprising EBD plus EST as the initial treatment for patients with moderate acute cholangitis due to choledocholithiasis was safe and did not prolong the period of hospitalization.
PURPOSE: We retrospectively assessed post-EST complications and examined whether combination therapy comprising endoscopic biliary drainage (EBD) plus endoscopic sphincterotomy (EST) as the initial treatment is safe in patients with acute cholangitis due to choledocholithiasis. METHODS: Among the 363 consecutive patients with acute cholangitis due to choledocholithiasis who were treated in our hospital between December 1992 and December 2006, the subjects comprised 127 patients with moderate acute cholangitis for whom EBD and EST were carried out. Factors influencing risk factors for post-EST pancreatitis, hemorrhage and hospitalization were determined by multivariate analysis. RESULTS: Multivariate analysis revealed that only precut sphincterotomy (PST) was a significant risk factor for post-EST pancreatitis, and the incidence of pancreatitis in patients who underwent PST was significantly higher than that in those who did not (P = 0.041). Only age was a significant risk factor for post-EST hemorrhage, and younger patients were likely to experience hemorrhage after EST (P = 0.021). Total bilirubin and the timing of EST were significant factors associated with hospitalization. Hospitalization in patients who underwent EBD plus EST as the initial treatment (emergency EST) was significantly shorter than that in those who palliatively underwent EST after EBD (elective EST; 11.8 vs. 16.2 days, P = 0.001). CONCLUSIONS: Combination therapy comprising EBD plus EST as the initial treatment for patients with moderate acute cholangitis due to choledocholithiasis was safe and did not prolong the period of hospitalization.
Authors: P B Cotton; G Lehman; J Vennes; J E Geenen; R C Russell; W C Meyers; C Liguory; N Nickl Journal: Gastrointest Endosc Date: 1991 May-Jun Impact factor: 9.427
Authors: M L Freeman; D B Nelson; S Sherman; G B Haber; M E Herman; P J Dorsher; J P Moore; M B Fennerty; M E Ryan; M J Shaw; J D Lande; A M Pheley Journal: N Engl J Med Date: 1996-09-26 Impact factor: 91.245
Authors: Keita Wada; Tadahiro Takada; Yoshifumi Kawarada; Yuji Nimura; Fumihiko Miura; Masahiro Yoshida; Toshihiko Mayumi; Steven Strasberg; Henry A Pitt; Thomas R Gadacz; Markus W Büchler; Jacques Belghiti; Eduardo de Santibanes; Dirk J Gouma; Horst Neuhaus; Christos Dervenis; Sheung-Tat Fan; Miin-Fu Chen; Chen-Guo Ker; Philippus C Bornman; Serafin C Hilvano; Sun-Whe Kim; Kui-Hin Liau; Myung-Hwan Kim Journal: J Hepatobiliary Pancreat Surg Date: 2007-01-30
Authors: Shaffer R S Mok; Christie L Mannino; Jessica Malin; Matthew E Drew; Patricia Henry; Punitha Shivaprasad; Barry Milcarek; Adam B Elfant; Thomas A Judge Journal: J Interv Gastroenterol Date: 2012-10-01