| Literature DB >> 19597708 |
Choong Hyun Lee1, Ki-Yeon Yoo, Jung Hoon Choi, Ok Kyu Park, In Koo Hwang, Il-Jun Kang, Moo-Ho Won.
Abstract
Cyclooxygenases-2 (COX-2) is not only related to inflammation but also plays critical roles in brain development and synaptic signaling. In the present study, we investigated age-related changes in COX-2 immunoreactivity and protein levels in the gerbil hippocampus. In the hippocampal CA1 region (CA1) and dentate gyrus (DG), weak COX-2 immunoreactivity was observed at postnatal month 1 (PM 1), and COX-2 immunoreactivity was markedly increased at PM 18 and 24. In the CA2/3, COX-2 immunoreactivity was strong at PM 1. COX-2 immunoreactivities in the PM 3, 6 and 12 groups were decreased compared to that in the PM 1 group, and it was increased at PM 18 and 24. In addition, age-related changes in COX-2 levels were similar with immunohistochemical results in the CA2/3. These results suggest that COX-2 immunoreactivity and levels were high in the hippocampus of aged gerbils.Entities:
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Year: 2009 PMID： 19597708 DOI： 10.1007/s11064-009-0034-5
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996