Literature DB >> 19597615

Remarkable effect of 2,2'-bipyridyl: mild and highly chemoselective deprotection of methoxymethyl (MOM) ethers in combination with TMSOTf (TESOTf)-2,2'-bipyridyl.

Hiromichi Fujioka1, Ozora Kubo, Kento Senami, Yutaka Minamitsuji, Tomohiro Maegawa.   

Abstract

The remarkable effect of 2,2'-bipyridyl led to the successful development of the mild and highly chemoselective deprotection method of methoxymethyl (MOM) ethers using the combination of TMSOTf (or TESOTf) and 2,2'-bipyridyl; this method can be applied to the direct conversion of the MOM group to other ethereal protective groups (e.g. benzyloxymethyl) with the corresponding alcohols.

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Year:  2009        PMID: 19597615     DOI: 10.1039/b907910f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  Expanded substrate scope and improved reactivity of ether-forming cross-coupling reactions of organotrifluoroborates and acetals.

Authors:  Cam-Van T Vo; T Andrew Mitchell; Jeffrey W Bode
Journal:  J Am Chem Soc       Date:  2011-08-17       Impact factor: 15.419

  1 in total

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