Literature DB >> 19596884

Differential expression of ccrA in methicillin-resistant Staphylococcus aureus strains carrying staphylococcal cassette chromosome mec type II and IVa elements.

Paul G Higgins1, Adriana E Rosato, Harald Seifert, Gordon L Archer, Hilmar Wisplinghoff.   

Abstract

Excision of staphylococcal cassette chromosome mec (SCCmec) is mediated through the ccrA- and -B-encoded recombinases. We investigated the effects of different antimicrobial agents on ccrA expression by using a ccrA::lacZ fusion and reverse transcription-PCR with methicillin (meticillin)-resistant Staphylococcus aureus strains MW2 (SCCmec IVa) and N315 (SCCmec II). Upregulation of ccrA was observed upon exposure to beta-lactam antibiotics. Vancomycin increased ccrA expression in MW2 but had no effect on N315. Vancomycin may contribute to the transfer of SCCmec IVa but have no effect in SCCmec II.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19596884      PMCID： PMC2764196          DOI： 10.1128/AAC.00395-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains.

Authors:  Xiao Xue Ma; Teruyo Ito; Chuntima Tiensasitorn; Mantana Jamklang; Piriyaporn Chongtrakool; Susan Boyle-Vavra; Robert S Daum; Keiichi Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  2002-04       Impact factor: 5.191

2.  In-vivo transfer of mecA DNA to Staphylococcus aureus [corrected].

Authors:  C L Wielders; M R Vriens; S Brisse; L A de Graaf-Miltenburg; A Troelstra; A Fleer; F J Schmitz; J Verhoef; A C Fluit
Journal:  Lancet       Date:  2001-05-26       Impact factor: 79.321

3.  Direct detection of Staphylococcus aureus mRNA using a flow through microarray.

Authors:  R M Anthony; A R J Schuitema; L Oskam; P R Klatser
Journal:  J Microbiol Methods       Date:  2005-01       Impact factor: 2.363

4.  Novel mobile variants of staphylococcal cassette chromosome mec in Staphylococcus aureus.

Authors:  W T M Jansen; M M Beitsma; C J Koeman; W J B van Wamel; J Verhoef; A C Fluit
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

5.  Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.

Authors:  Rebecca Steidl; Stacy Pearson; Robert E Stephenson; Nagender Ledala; Sutthirat Sitthisak; Brian J Wilkinson; Radheshyam K Jayaswal
Journal:  Antimicrob Agents Chemother       Date:  2008-06-09       Impact factor: 5.191

6.  A subset of Staphylococcus aureus strains harboring staphylococcal cassette chromosome mec (SCCmec) type IV is deficient in CcrAB-mediated SCCmec excision.

Authors:  Michael J Noto; Gordon L Archer
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

7.  Interaction of native and mutant MecI repressors with sequences that regulate mecA, the gene encoding penicillin binding protein 2a in methicillin-resistant staphylococci.

Authors:  V K Sharma; C J Hackbarth; T M Dickinson; G L Archer
Journal:  J Bacteriol       Date:  1998-04       Impact factor: 3.490

8.  Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus.

Authors:  T Ito; Y Katayama; K Asada; N Mori; K Tsutsumimoto; C Tiensasitorn; K Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

9.  Transcription of the gene mediating methicillin resistance in Staphylococcus aureus (mecA) is corepressed but not coinduced by cognate mecA and beta-lactamase regulators.

Authors:  T K McKinney; V K Sharma; W A Craig; G L Archer
Journal:  J Bacteriol       Date:  2001-12       Impact factor: 3.490

10.  Phenotypic expression of oxacillin resistance in Staphylococcus epidermidis: roles of mecA transcriptional regulation and resistant-subpopulation selection.

Authors:  T M Dickinson; G L Archer
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191
View more
  12 in total

1.  Novel Type XII Staphylococcal Cassette Chromosome mec Harboring a New Cassette Chromosome Recombinase, CcrC2.

Authors:  Zhaowei Wu; Fan Li; Dongliang Liu; Huping Xue; Xin Zhao
Journal:  Antimicrob Agents Chemother       Date:  2015-09-28       Impact factor: 5.191

2.  Tandem Amplification of the Staphylococcal Cassette Chromosome mec Element Can Drive High-Level Methicillin Resistance in Methicillin-Resistant Staphylococcus aureus.

Authors:  Laura A Gallagher; Simone Coughlan; Nikki S Black; Pierce Lalor; Elaine M Waters; Bryan Wee; Mick Watson; Tim Downing; J Ross Fitzgerald; Gerard T A Fleming; James P O'Gara
Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

3.  Cross-species spread of SCCmec IV subtypes in staphylococci.

Authors:  Davida S Smyth; Agnes Wong; D Ashley Robinson
Journal:  Infect Genet Evol       Date:  2010-12-21       Impact factor: 3.342

4.  A Plasmid-Borne System To Assess the Excision and Integration of Staphylococcal Cassette Chromosome mec Mediated by CcrA and CcrB.

Authors:  Lei Wang; Mostafa H Ahmed; Martin K Safo; Gordon L Archer
Journal:  J Bacteriol       Date:  2015-06-08       Impact factor: 3.490

5.  Characterization of ocular methicillin-resistant Staphylococcus epidermidis isolates belonging predominantly to clonal complex 2 subcluster II.

Authors:  Paulo J M Bispo; Ana Luisa Hofling-Lima; Antonio C C Pignatari
Journal:  J Clin Microbiol       Date:  2014-02-12       Impact factor: 5.948

6.  Combinations of cefoxitin plus other β-lactams are synergistic in vitro against community associated methicillin-resistant Staphylococcus aureus.

Authors:  R Banerjee; M G Fernandez; N Enthaler; C Graml; K E Greenwood-Quaintance; R Patel
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2013-01-23       Impact factor: 3.267

7.  Modulation of ccrAB Expression and SCCmec Excision by an Inverted Repeat Element and SarS in Methicillin-Resistant Staphylococcus aureus.

Authors:  Shijie Zhang; Ronghua Ma; Xiaoyu Liu; Xu Zhang; Baolin Sun
Journal:  Antimicrob Agents Chemother       Date:  2015-07-27       Impact factor: 5.191

8.  Transfer of the methicillin resistance genomic island among staphylococci by conjugation.

Authors:  M D Ray; S Boundy; G L Archer
Journal:  Mol Microbiol       Date:  2016-03-14       Impact factor: 3.501

9.  A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus.

Authors:  Marios Arvanitis; Gang Li; De-Dong Li; Daniel Cotnoir; Lisa Ganley-Leal; Daniel W Carney; Jason K Sello; Eleftherios Mylonakis
Journal:  PLoS One       Date:  2016-04-21       Impact factor: 3.240

10.  Excision of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus assessed by quantitative PCR.

Authors:  Miloš Stojanov; P Moreillon; O Sakwinska
Journal:  BMC Res Notes       Date:  2015-12-29
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.