Literature DB >> 1959644

Modified low density lipoproteins activate human macrophages to secrete immunoreactive endothelin.

F Martin-Nizard1, H S Houssaini, S Lestavel-Delattre, P Duriez, J C Fruchart.   

Abstract

This study attempted to determine if low density lipoproteins (LDL) induce the production of endothelins (ET) by human macrophages. Non-protected LDL from macrophage induced oxidation (n-LDL), copper-oxidized LDL (Ox-LDL), acetylated-LDL (Ac-LDL), butylated hydroxytoluene-LDL (BHT-LDL), BHT-Ac-LDL, polyinosinic acid (PiA, 1.5 micrograms/ml), phorbol myristate acetate (PMA; 0.5 microM) and BHT alone (20 microM) were studied. The different compounds had the following potency to stimulate the ET secretion: PMA greater than Ox-LDL greater than Ac-LDL greater than n-LDL greater than BHT-LDL greater than PiA greater than PiA + Ac-LDL greater than BHT. In conclusion, modified LDL stimulated ET secretion by human macrophages.

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Year:  1991        PMID： 1959644     DOI： 10.1016/0014-5793(91)81167-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

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Review 2.  [Endothelial dysfunction--assessment of current status and approaches to therapy].

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Authors:  M C Kowala; P M Rose; P D Stein; N Goller; R Recce; S Beyer; M Valentine; D Barton; S K Durham
Journal:  Am J Pathol       Date:  1995-04       Impact factor: 4.307

4.  Localization and production of immunoreactive endothelin-1 in the trophoblast of human placenta.

Authors:  A Malassiné; L Cronier; F Mondon; T M Mignot; F Ferré
Journal:  Cell Tissue Res       Date:  1993-03       Impact factor: 5.249

5.  Suppression of endothelin-1-induced mitogenic responses of human aortic smooth muscle cells by interleukin-1 beta.

Authors:  Y Fujitani; H Ninomiya; T Okada; Y Urade; T Masaki
Journal:  J Clin Invest       Date:  1995-06       Impact factor: 14.808

Review 6.  The heart as an extravascular target of endothelin-1 in particulate matter-induced cardiac dysfunction.

Authors:  Elizabeth A W Chan; Barbara Buckley; Aimen K Farraj; Leslie C Thompson
Journal:  Pharmacol Ther       Date:  2016-05-21       Impact factor: 12.310

7.  Up-regulation of endothelin-1 mRNA and peptide expression in rat cardiac allografts with rejection and arteriosclerosis.

Authors:  B Watschinger; M H Sayegh; W W Hancock; M E Russell
Journal:  Am J Pathol       Date:  1995-05       Impact factor: 4.307
  7 in total

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