| Literature DB >> 19596114 |
Tetsu Kurokawa1, Yasunobu Yumiya, Hirosuke Fujisawa, Satoshi Shirao, Shiro Kashiwagi, Masafumi Sato, Hiroko Kishi, Saori Miwa, Kimiko Mogami, Shoichi Kato, Tatsuo Akimura, Masaaki Soma, Kuniaki Ogasawara, Akira Ogawa, Sei Kobayashi, Michiyasu Suzuki.
Abstract
This study investigates the role of sphingosylphosphorylcholine (SPC) in the mechanisms underlying cerebral vasospasm after subarachnoid hemorrhage (SAH). The levels of SPC were measured in cerebrospinal fluid (CSF) of patients with SAH and also in an experimental canine model. CSF samples were collected from 11 patients with SAH, and from dogs that had received an injection of SPC into the cisterna magna to examine SPC kinetics in the CSF. SPC was assayed using solid-phase extraction and triple quadrupole mass spectrometry. The SPC concentrations in SAH patients on days 3, 8, and 14 after the onset of SAH were significantly higher than those in normal CSF. In the canine model, rapid dilution of SPC in CSF was observed. In combination with data from previous studies, these results suggest that SPC is involved in the development of cerebral vasospasm. Rapid dilution of SPC in CSF suggests that SPC is released into CSF at higher concentrations than those measured in the present study.Entities:
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Year: 2009 PMID： 19596114 DOI： 10.1016/j.jocn.2009.01.010
Source DB: PubMed Journal: J Clin Neurosci ISSN： 0967-5868 Impact factor: 1.961