| Literature DB >> 19596003 |
Nobuhisa Nakamura1, Keiko Naruse, Takashi Matsuki, Yoji Hamada, Eitaro Nakashima, Hideki Kamiya, Tatsuaki Matsubara, Atsushi Enomoto, Masahide Takahashi, Yutaka Oiso, Jiro Nakamura.
Abstract
Adiponectin has anti-atherosclerotic effects through its direct actions on vascular cells. The present study investigates the molecular mechanisms of adiponectin in the migration of endothelial progenitor cells (EPCs) which play an important role in neovascularization and re-endothelization. The phosphorylation of Akt and the activations of Cdc42 and Rac1 were significantly increased by adiponectin. Adiponectin increased the migration activity of EPCs, which was completely inhibited by a PI3-kinase inhibitor. siRNA of Cdc42 or Rac1 completely inhibited the adiponectin-induced migration, but siRNA of Akt had no effects, indicating that adiponectin promotes the migration activities of EPCs mainly through PI3-kinase/Cdc42/Rac1.Entities:
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Year: 2009 PMID： 19596003 DOI： 10.1016/j.febslet.2009.07.011
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124