Literature DB >> 1959576

Plasmodium yoelii: oral delivery of 5-fluoroorotate to treat malaria in mice.

P K Rathod1, Z M Gomez.   

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Year:  1991        PMID: 1959576     DOI: 10.1016/0014-4894(91)90075-8

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN: 0014-4894            Impact factor:   2.011


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  11 in total

Review 1.  Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.

Authors:  Alexis Nzila; Steve A Ward; Kevin Marsh; Paul F G Sims; John E Hyde
Journal:  Trends Parasitol       Date:  2005-06

2.  Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.

Authors:  L Jiang; P C Lee; J White; P K Rathod
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

Review 3.  Targeting purine and pyrimidine metabolism in human apicomplexan parasites.

Authors:  John E Hyde
Journal:  Curr Drug Targets       Date:  2007-01       Impact factor: 3.465

4.  Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694.

Authors:  M Hekmat-Nejad; P K Rathod
Journal:  Antimicrob Agents Chemother       Date:  1996-07       Impact factor: 5.191

5.  Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.

Authors:  S Gassis; P K Rathod
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

6.  Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.

Authors:  P K Rathod; S Reshmi
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

7.  Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum.

Authors:  P K Rathod; M Khosla; S Gassis; R D Young; C Lutz
Journal:  Antimicrob Agents Chemother       Date:  1994-12       Impact factor: 5.191

8.  Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum.

Authors:  P K Rathod; N P Leffers; R D Young
Journal:  Antimicrob Agents Chemother       Date:  1992-04       Impact factor: 5.191

9.  Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate.

Authors:  R D Young; P K Rathod
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191

10.  Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.

Authors:  Francis W Muregi; Akira Ishih
Journal:  Drug Dev Res       Date:  2010-02       Impact factor: 4.360

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