Literature DB >> 19595622

Experimental modelling of aortic aneurysms: novel applications of silicone rubbers.

Barry J Doyle1, Timothy J Corbett, Aidan J Cloonan, Michael R O'Donnell, Michael T Walsh, David A Vorp, Timothy M McGloughlin.   

Abstract

A range of silicone rubbers were created based on existing commercially available materials. These silicones were designed to be visually different from one another and have distinct material properties, in particular, ultimate tensile strengths and tear strengths. In total, eleven silicone rubbers were manufactured, with the materials designed to have a range of increasing tensile strengths from approximately 2 to 4 MPa, and increasing tear strengths from approximately 0.45 to 0.7 N/mm. The variations in silicones were detected using a standard colour analysis technique. Calibration curves were then created relating colour intensity to individual material properties. All eleven materials were characterised and a 1st order Ogden strain energy function applied. Material coefficients were determined and examined for effectiveness. Six idealised abdominal aortic aneurysm models were also created using the two base materials of the study, with a further model created using a new mixing technique to create a rubber model with randomly assigned material properties. These models were then examined using videoextensometry and compared to numerical results. Colour analysis revealed a statistically significant linear relationship (p<0.0009) with both tensile strength and tear strength, allowing material strength to be determined using a non-destructive experimental technique. The effectiveness of this technique was assessed by comparing predicted material properties to experimentally measured methods, with good agreement in the results. Videoextensometry and numerical modelling revealed minor percentage differences, with all results achieving significance (p<0.0009). This study has successfully designed and developed a range of silicone rubbers that have unique colour intensities and material strengths. Strengths can be readily determined using a non-destructive analysis technique with proven effectiveness. These silicones may further aid towards an improved understanding of the biomechanical behaviour of aneurysms using experimental techniques.

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Year:  2009        PMID: 19595622      PMCID: PMC2757445          DOI: 10.1016/j.medengphy.2009.06.002

Source DB:  PubMed          Journal:  Med Eng Phys        ISSN: 1350-4533            Impact factor:   2.242


  19 in total

1.  In vivo analysis of mechanical wall stress and abdominal aortic aneurysm rupture risk.

Authors:  Mark F Fillinger; M L Raghavan; Steven P Marra; Jack L Cronenwett; Francis E Kennedy
Journal:  J Vasc Surg       Date:  2002-09       Impact factor: 4.268

2.  An experimental and numerical comparison of the rupture locations of an abdominal aortic aneurysm.

Authors:  Barry J Doyle; Timothy J Corbett; Anthony Callanan; Michael T Walsh; David A Vorp; Timothy M McGloughlin
Journal:  J Endovasc Ther       Date:  2009-06       Impact factor: 3.487

3.  Mechanical wall stress in abdominal aortic aneurysm: influence of diameter and asymmetry.

Authors:  D A Vorp; M L Raghavan; M W Webster
Journal:  J Vasc Surg       Date:  1998-04       Impact factor: 4.268

4.  Ex vivo biomechanical behavior of abdominal aortic aneurysm: assessment using a new mathematical model.

Authors:  M L Raghavan; M W Webster; D A Vorp
Journal:  Ann Biomed Eng       Date:  1996 Sep-Oct       Impact factor: 3.934

5.  Aneurysm wall stress and tendency to rupture are features of physical wall properties: an experimental study.

Authors:  Harpaul S Flora; Bijan Talei-Faz; Leslie Ansdell; Edmund J Chaloner; Aaron Sweeny; Anthony Grass; Mohan Adiseshiah
Journal:  J Endovasc Ther       Date:  2002-10       Impact factor: 3.487

6.  Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter.

Authors:  Mark F Fillinger; Steven P Marra; M L Raghavan; Francis E Kennedy
Journal:  J Vasc Surg       Date:  2003-04       Impact factor: 4.268

7.  Wall stress distribution on three-dimensionally reconstructed models of human abdominal aortic aneurysm.

Authors:  M L Raghavan; D A Vorp; M P Federle; M S Makaroun; M W Webster
Journal:  J Vasc Surg       Date:  2000-04       Impact factor: 4.268

8.  Mechanical properties of abdominal aortic aneurysm wall.

Authors:  M J Thubrikar; M Labrosse; F Robicsek; J Al-Soudi; B Fowler
Journal:  J Med Eng Technol       Date:  2001 Jul-Aug

9.  A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms.

Authors:  A K Venkatasubramaniam; M J Fagan; T Mehta; K J Mylankal; B Ray; G Kuhan; I C Chetter; P T McCollum
Journal:  Eur J Vasc Endovasc Surg       Date:  2004-08       Impact factor: 7.069

10.  Effect of intraluminal thrombus on wall stress in patient-specific models of abdominal aortic aneurysm.

Authors:  David H J Wang; Michel S Makaroun; Marshall W Webster; David A Vorp
Journal:  J Vasc Surg       Date:  2002-09       Impact factor: 4.268

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  5 in total

1.  A Brush-Spin-Coating Method for Fabricating In Vitro Patient-Specific Vascular Models by Coupling 3D-Printing.

Authors:  Qing-Zhuo Chi; Li-Zhong Mu; Ying He; Yong Luan; Yu-Chen Jing
Journal:  Cardiovasc Eng Technol       Date:  2020-12-02       Impact factor: 2.495

2.  3D-Printed Tissue-Mimicking Phantoms for Medical Imaging and Computational Validation Applications.

Authors:  Aidan J Cloonan; Danial Shahmirzadi; Ronny X Li; Barry J Doyle; Elisa E Konofagou; Tim M McGloughlin
Journal:  3D Print Addit Manuf       Date:  2014-03-01       Impact factor: 5.449

3.  Identification of rupture locations in patient-specific abdominal aortic aneurysms using experimental and computational techniques.

Authors:  Barry J Doyle; Aidan J Cloonan; Michael T Walsh; David A Vorp; Timothy M McGloughlin
Journal:  J Biomech       Date:  2010-02-12       Impact factor: 2.712

Review 4.  A Review of Computational Methods to Predict the Risk of Rupture of Abdominal Aortic Aneurysms.

Authors:  Tejas Canchi; S D Kumar; E Y K Ng; Sriram Narayanan
Journal:  Biomed Res Int       Date:  2015-10-05       Impact factor: 3.411

5.  Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation.

Authors:  Doran S Mix; Michael C Stoner; Steven W Day; Michael S Richards
Journal:  J Vis Exp       Date:  2018-09-19       Impact factor: 1.355

  5 in total

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