Francis Couturaud1, Christophe Leroyer2, Jim A Julian3, Susan R Kahn4, Jeffrey S Ginsberg3, Philip S Wells5, James D Douketis3, Dominique Mottier2, Clive Kearon3. 1. Department of Internal Medicine and Chest Diseases, Groupe d'Etude de la Thrombose de Bretagne Occidentale, Brest, France. Electronic address: francis.couturaud@chu-brest.fr. 2. Department of Internal Medicine and Chest Diseases, Groupe d'Etude de la Thrombose de Bretagne Occidentale, Brest, France. 3. McMaster University and the Henderson Research Centre, Hamilton, ON, Canada. 4. McGill University, Montreal, QC, Canada. 5. Ottawa University, Ottawa, ON, Canada.
Abstract
BACKGROUND: Factors that predict the risk of venous thromboembolism in the first-degree relatives of patients with unprovoked venous thromboembolism are uncertain but important for counseling. We aimed to identify risk factors for, and quantify the risk of, venous thromboembolism in first-degree relatives of patients (index case patients) with a first episode of unprovoked venous thromboembolism. METHODS: In a cross-sectional study, using a standardized method and without knowledge of whether patients or their relatives had thrombophilia, we assessed the prevalence of previous venous thromboembolism in 1,916 first-degree relatives of 378 unselected patients with a first episode of unprovoked venous thromboembolism. Patient characteristics, and the presence of factor V Leiden or the G20210A prothrombin gene mutation in patients, were assessed as predictors of venous thromboembolism in patient's relatives. RESULTS: There were 102 previous episodes of venous thromboembolism in the first-degree relatives (prevalence, 5.3%). Thrombosis at a young age in patients was the strongest predictor of venous thromboembolism in relatives, with an adjusted odds ratio (OR) for younger patients (ie, patients < 45 years of age when venous thromboembolism occurred; lowest quartile) compared with older patients (ie, patients > 71 years of age; highest quartile) of 3.27 (95% CI, 1.68 to 6.38). The presence of factor V Leiden or the G20210A prothrombin gene in patients was a weak independent predictor of venous thromboembolism in relatives (adjusted OR, 1.48; 95% CI, 0.94 to 2.33). CONCLUSION: Unprovoked venous thromboembolism at a young age is associated with a substantially increased risk of venous thromboembolism in patients' families.
BACKGROUND: Factors that predict the risk of venous thromboembolism in the first-degree relatives of patients with unprovoked venous thromboembolism are uncertain but important for counseling. We aimed to identify risk factors for, and quantify the risk of, venous thromboembolism in first-degree relatives of patients (index case patients) with a first episode of unprovoked venous thromboembolism. METHODS: In a cross-sectional study, using a standardized method and without knowledge of whether patients or their relatives had thrombophilia, we assessed the prevalence of previous venous thromboembolism in 1,916 first-degree relatives of 378 unselected patients with a first episode of unprovoked venous thromboembolism. Patient characteristics, and the presence of factor V Leiden or the G20210Aprothrombin gene mutation in patients, were assessed as predictors of venous thromboembolism in patient's relatives. RESULTS: There were 102 previous episodes of venous thromboembolism in the first-degree relatives (prevalence, 5.3%). Thrombosis at a young age in patients was the strongest predictor of venous thromboembolism in relatives, with an adjusted odds ratio (OR) for younger patients (ie, patients < 45 years of age when venous thromboembolism occurred; lowest quartile) compared with older patients (ie, patients > 71 years of age; highest quartile) of 3.27 (95% CI, 1.68 to 6.38). The presence of factor V Leiden or the G20210Aprothrombin gene in patients was a weak independent predictor of venous thromboembolism in relatives (adjusted OR, 1.48; 95% CI, 0.94 to 2.33). CONCLUSION: Unprovoked venous thromboembolism at a young age is associated with a substantially increased risk of venous thromboembolism in patients' families.
Authors: Francis Couturaud; Christophe Leroyer; Cecile Tromeur; Jim A Julian; Susan R Kahn; Jeffrey S Ginsberg; Philip S Wells; James D Douketis; Dominique Mottier; Clive Kearon Journal: Blood Date: 2014-07-21 Impact factor: 22.113
Authors: Su Yeon Lee; Eun Kyoug Kim; Min Sun Kim; Sun Hye Shin; Haseong Chang; Shin Yi Jang; Hee-Jin Kim; Duk-Kyung Kim Journal: PLoS One Date: 2017-10-17 Impact factor: 3.240