| Literature DB >> 19592242 |
Darby Schmidt1, Abigail Smenton, Subharekha Raghavan, Ester Carballo-Jane, Silvi Lubell, Tanya Ciecko, Tom G Holt, Michael Wolff, Andrew Taggart, Larissa Wilsie, Mihajlo Krsmanovic, Ning Ren, Daniel Blom, Kang Cheng, Peggy E McCann, M Gerard Waters, James Tata, Steven Colletti.
Abstract
Niacin is an effective drug for raising HDL cholesterol and reducing coronary risks, but patients show low compliance with treatment due to severe facial flushing upon taking the drug. A series of bicyclic pyrazole carboxylic acids were synthesized and tested for their ability to activate the niacin receptor. One analog, 23, showed improved potency and lacked flushing at doses that effectively altered the lipid profile of rats.Entities:
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Year: 2009 PMID： 19592242 DOI： 10.1016/j.bmcl.2009.06.054
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823