Literature DB >> 19592124

Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: case-parent design.

Bárbara Angel1, Iván Balic, José Luis Santos, Ethel Codner, Elena Carrasco, Francisco Pérez-Bravo.   

Abstract

CTLA-4 plays a key role in T cells regulation. We analysed the CTLA-4 +49A/G and -318C/T polymorphisms in 178 cases of type 1 diabetes and their parents (534 individuals) from Santiago, Chile. A significant overall association with T1D (p=0.028) was observed, possibly due to an overtransmission of the G-T haplotype.

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Year:  2009        PMID： 19592124     DOI： 10.1016/j.diabres.2009.05.019

Source DB:  PubMed          Journal:  Diabetes Res Clin Pract        ISSN： 0168-8227            Impact factor:   5.602


  2 in total

1.  Association of CLTA-4 Gene Polymorphisms with Diabetes Mellitus: A Study Based on the Han Population of Northern China.

Authors:  Dongyue Ren; Lin He; Xiaoling Pang
Journal:  Diabetes Metab Syndr Obes       Date:  2022-09-03       Impact factor: 3.249

2.  CTLA-4 (+49A/G) polymorphism and type-1 diabetes in Turkish children.

Authors:  Fatih Çelmeli; Doğa Türkkahraman; Deniz Özel; Sema Akçurin; Olcay Yegin
Journal:  J Clin Res Pediatr Endocrinol       Date:  2013-07-01
  2 in total

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