Literature DB >> 19591934

Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke.

Xu Cui1, Michael Chopp, Alex Zacharek, Cynthia Roberts, Mei Lu, Smita Savant-Bhonsale, Jieli Chen.   

Abstract

We investigated the additive therapeutic effect of the combination treatment of stroke with sub-therapeutic doses of Simvastatin, a HMG-CoA reductase inhibitor, and bone marrow stromal cells (BMSCs). Rats were administered Simvastatin (0.5 mg/kg), BMSCs (1x10(6)) or combination of Simvastatin and BMSCs starting at 24 h after stroke. Combination treatment significantly improved neurological outcome, enhanced angiogenesis and arteriogenesis, and increased the number of engrafted-BMSCs in the ischemic brain. The number of engrafted-BMSCs and arteriogenesis was significantly correlated with functional outcome. Simvastatin significantly increased stromal cell-derived factor-1 (SDF1) expression in the ischemic brain and chemokine (CXC motif) receptor-4 (CXCR4) in BMSCs, and increased BMSC migration to RBMECs and astrocytes. Combination treatment of stroke upregulates the SDF1/CXCR4 axis and enhances BMSC migration into the ischemic brain, amplifies arteriogenesis and angiogenesis, and improves functional outcome after stroke.

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Year:  2009        PMID： 19591934      PMCID： PMC2748847          DOI： 10.1016/j.nbd.2009.06.012

Source DB:  PubMed          Journal:  Neurobiol Dis        ISSN： 0969-9961            Impact factor:   5.996


  41 in total

Review 1.  Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis).

Authors:  Matthias Heil; Wolfgang Schaper
Journal:  Circ Res       Date:  2004-09-03       Impact factor: 17.367

2.  Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia.

Authors:  Alejandro R Chade; Xiangyang Zhu; Oren P Mushin; Claudio Napoli; Amir Lerman; Lilach O Lerman
Journal:  FASEB J       Date:  2006-06-21       Impact factor: 5.191

3.  Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.

Authors:  Minoru Asahi; Zhihong Huang; Sunu Thomas; Shin-ichi Yoshimura; Toshihisa Sumii; Tatsuro Mori; Jianhua Qiu; Sepideh Amin-Hanjani; Paul L Huang; James K Liao; Eng H Lo; Michael A Moskowitz
Journal:  J Cereb Blood Flow Metab       Date:  2005-06       Impact factor: 6.200

Review 4.  Neurorestorative treatment of stroke: cell and pharmacological approaches.

Authors:  Jieli Chen; Michael Chopp
Journal:  NeuroRx       Date:  2006-10

5.  Angiographic assessment of pial collaterals as a prognostic indicator following intra-arterial thrombolysis for acute ischemic stroke.

Authors:  Gregory A Christoforidis; Yousef Mohammad; Dimitris Kehagias; Bindu Avutu; Andrew P Slivka
Journal:  AJNR Am J Neuroradiol       Date:  2005-08       Impact factor: 3.825

6.  Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction.

Authors:  Yao Liang Tang; Qiang Zhao; Xinyu Qin; Leping Shen; Leilei Cheng; Junbo Ge; M Ian Phillips
Journal:  Ann Thorac Surg       Date:  2005-07       Impact factor: 4.330

Review 7.  Pathophysiology and therapy of experimental stroke.

Authors:  Konstantin-Alexander Hossmann
Journal:  Cell Mol Neurobiol       Date:  2006-05-19       Impact factor: 5.046

Review 8.  CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion.

Authors:  Magda Kucia; Kacper Jankowski; Ryan Reca; Marcin Wysoczynski; Laura Bandura; Daniel J Allendorf; Jin Zhang; Janina Ratajczak; Mariusz Z Ratajczak
Journal:  J Mol Histol       Date:  2004-03       Impact factor: 2.611

9.  The surface adhesion molecule CXCR4 stimulates mesenchymal stem cell migration to stromal cell-derived factor-1 in vitro but does not decrease apoptosis under serum deprivation.

Authors:  Shyam Bhakta; Ping Hong; Omer Koc
Journal:  Cardiovasc Revasc Med       Date:  2006 Jan-Mar

Review 10.  Arteriogenesis versus angiogenesis: similarities and differences.

Authors:  M Heil; Inka Eitenmüller; T Schmitz-Rixen; W Schaper
Journal:  J Cell Mol Med       Date:  2006 Jan-Mar       Impact factor: 5.310
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  33 in total

1.  Therapeutic benefit of treatment of stroke with simvastatin and human umbilical cord blood cells: neurogenesis, synaptic plasticity, and axon growth.

Authors:  Xu Cui; Michael Chopp; Amjad Shehadah; Alex Zacharek; Nicole Kuzmin-Nichols; Cyndy Davis Sanberg; Junhao Dai; Chunling Zhang; Yuji Ueno; Cynthia Roberts; Jieli Chen
Journal:  Cell Transplant       Date:  2012-03-08       Impact factor: 4.064

2.  Use of Statins to Augment Progenitor Cell Function in Preclinical and Clinical Studies of Regenerative Therapy: a Systematic Review.

Authors:  Angela Park; Juliana Barrera-Ramirez; Indee Ranasinghe; Sophie Pilon; Richmond Sy; Dean Fergusson; David S Allan
Journal:  Stem Cell Rev Rep       Date:  2016-06       Impact factor: 5.739

3.  Neuroprotective effect of bone marrow stromal cell combination with atorvastatin in rat model of spinal cord injury.

Authors:  Fang Li; Dan Fei; Libo Sun; Sixun Zhang; Yue Yuan; Li Zhang; Kuiming Zhao; Rui Li; Yanbing Yu
Journal:  Int J Clin Exp Med       Date:  2014-12-15

4.  Evaluation of Simvastatin and Bone Marrow-Derived Mesenchymal Stem Cell Combination Therapy on Airway Remodeling in a Mouse Asthma Model.

Authors:  Maryam Mohammadian; Hamid Reza Sadeghipour; Iraj Ragerdi Kashani; Gila Pirzad Jahromi; Amene Omidi; Amir Kavian Nejad; Ravie Golchoobian; Mohammad Hossein Boskabady
Journal:  Lung       Date:  2016-05-09       Impact factor: 2.584

Review 5.  Cell based therapies for ischemic stroke: from basic science to bedside.

Authors:  Xinfeng Liu; Ruidong Ye; Tao Yan; Shan Ping Yu; Ling Wei; Gelin Xu; Xinying Fan; Yongjun Jiang; R Anne Stetler; George Liu; Jieli Chen
Journal:  Prog Neurobiol       Date:  2013-12-12       Impact factor: 11.685

6.  Exogenous and endogenous therapeutic effects of combination Sodium Ferulate and bone marrow stromal cells (BMSCs) treatment enhance neurogenesis after rat focal cerebral ischemia.

Authors:  Yonghua Zhao; Wan Lai; Youhua Xu; Liming Li; Zhenwei Chen; Weikang Wu
Journal:  Metab Brain Dis       Date:  2013-08-17       Impact factor: 3.584

7.  Bone Marrow Stromal Cells Combined With Sodium Ferulate and n-Butylidenephthalide Promote the Effect of Therapeutic Angiogenesis via Advancing Astrocyte-Derived Trophic Factors After Ischemic Stroke.

Authors:  Qian Zhang; Zhen-Wei Chen; Yong-Hua Zhao; Bo-Wen Liu; Nai-Wei Liu; Chien-Chih Ke; Hong-Mei Tan
Journal:  Cell Transplant       Date:  2016-10-21       Impact factor: 4.064

8.  Combined therapy with atorvastatin and atorvastatin-pretreated mesenchymal stem cells enhances cardiac performance after acute myocardial infarction by activating SDF-1/CXCR4 axis.

Authors:  Xia-Qiu Tian; Yue-Jin Yang; Qing Li; Jun Xu; Pei-Sen Huang; Yu-Yan Xiong; Xiang-Dong Li; Chen Jin; Kang Qi; Lei-Pei Jiang; Gui-Hao Chen; Li Qian; Jiandong Liu; Yong-Jian Geng
Journal:  Am J Transl Res       Date:  2019-07-15       Impact factor: 4.060

9.  Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves functional outcome.

Authors:  X Cui; M Chopp; A Zacharek; J Dai; C Zhang; T Yan; R Ning; C Roberts; A Shehadah; N Kuzmin-Nichols; C D Sanberg; J Chen
Journal:  Neuroscience       Date:  2012-10-04       Impact factor: 3.590

10.  Atorvastatin Modulates Regulatory T Cells and Attenuates Cerebral Damage in a Model of Transient Middle Cerebral Artery Occlusion in Rats.

Authors:  Ana Lucía Rodríguez-Perea; Johanna Gutierrez-Vargas; Gloria Patricia Cardona-Gómez; Carlos Julio Montoya Guarin; Mauricio Rojas; Paula Andrea Velilla Hernández
Journal:  J Neuroimmune Pharmacol       Date:  2016-09-10       Impact factor: 4.147
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