Mark P Jensen1, Yu-Kun Chiang, Jacqueline Wu. 1. Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA 98195-6490, USA. mjensen@u.washington.edu
Abstract
OBJECTIVE: To replicate and extend previous research concerning the validity and utility of using pain quality measures in clinical trials. METHODS:One hundred fifty-eight patients with moderate-to-severe postherpetic neuralgia were randomly assigned to 1 of 3 treatment conditions: (1) extended release gabapentin (G-ER) 1800 mg once-daily administered in the evening; (2) G-ER 1800 mg asymmetric divided dose (600 mg AM and 1200 mg PM); or (3) placebo G-ER. A measure of different pain qualities, the Neuropathic Pain Scale, was administered as a secondary measure in this study before, during, and after the treatment. RESULTS: The results suggest that G-ER, especially when administered twice-daily, have the greatest effects on sharp, dull, sensitive, and itchy pain. Few between-condition effects were found for the global ratings of intensity or unpleasantness, and for hot, cold, deep, or surface pain qualities. CONCLUSIONS: The results provide further support for the importance of assessing specific pain qualities as outcomes in clinical trials. The findings may also be used by clinicians for identifying those patients for whom G-ER may be particularly effective; that is, patients with postherpetic neuralgia presenting with pain described as sharp, dull, sensitive, or itchy.
RCT Entities:
OBJECTIVE: To replicate and extend previous research concerning the validity and utility of using pain quality measures in clinical trials. METHODS: One hundred fifty-eight patients with moderate-to-severe postherpetic neuralgia were randomly assigned to 1 of 3 treatment conditions: (1) extended release gabapentin (G-ER) 1800 mg once-daily administered in the evening; (2) G-ER 1800 mg asymmetric divided dose (600 mg AM and 1200 mg PM); or (3) placebo G-ER. A measure of different pain qualities, the Neuropathic Pain Scale, was administered as a secondary measure in this study before, during, and after the treatment. RESULTS: The results suggest that G-ER, especially when administered twice-daily, have the greatest effects on sharp, dull, sensitive, and itchy pain. Few between-condition effects were found for the global ratings of intensity or unpleasantness, and for hot, cold, deep, or surface pain qualities. CONCLUSIONS: The results provide further support for the importance of assessing specific pain qualities as outcomes in clinical trials. The findings may also be used by clinicians for identifying those patients for whom G-ER may be particularly effective; that is, patients with postherpetic neuralgia presenting with pain described as sharp, dull, sensitive, or itchy.
Authors: Christine Miaskowski; Judy Mastick; Steven M Paul; Kimberly Topp; Betty Smoot; Gary Abrams; Lee-May Chen; Kord M Kober; Yvette P Conley; Margaret Chesney; Kay Bolla; Grace Mausisa; Melissa Mazor; Melisa Wong; Mark Schumacher; Jon D Levine Journal: J Pain Symptom Manage Date: 2017-01-04 Impact factor: 3.612
Authors: Philip J Wiffen; Sheena Derry; Rae F Bell; Andrew Sc Rice; Thomas Rudolf Tölle; Tudor Phillips; R Andrew Moore Journal: Cochrane Database Syst Rev Date: 2017-06-09
Authors: Daniel Bates; B Carsten Schultheis; Michael C Hanes; Suneil M Jolly; Krishnan V Chakravarthy; Timothy R Deer; Robert M Levy; Corey W Hunter Journal: Pain Med Date: 2019-06-01 Impact factor: 3.750