Literature DB >> 19590473

Randomized, double blinded comparative trial of intradermal injections of lignocaine versus N-saline around the knee to relieve pain in patients awaiting total knee replacement.

Terence Edward Loughnan1, Murray G Taverner, Ashley Webb.   

Abstract

OBJECTIVES: We report a randomized, double-blinded comparative study assessing the efficacy of local anesthetic with N-saline intradermal blocks around the knee to reduce pain and improve patient satisfaction while waiting for a total knee joint replacement.
METHODS: Patients were offered involvement in this study while on the hospital waiting list for a knee replacement. Eligible patients, after completing a prestudy assessment, received an average of 6.3 (range: 1 to 10) intradermal injections of 0.5 mL either saline or 1% lignocaine injections into tender points around the knee. Patients were assessed at 2 hours and 1 week after the injections. Pain was assessed using 0 to 100 visual analog pain scale. Global perceived effect (satisfaction) was measured on a 7-point Likert scale.
RESULTS: Thirty-two of 34 patients attended at 1-week assessment, 24 (75%) felt that they were improved, and 8 (25%) considered they were unchanged or worse. In both the saline and lignocaine groups, 12 of 16 patients felt that they had improved. N-saline proved as effective as lignocaine in reducing knee pain when injected intradermally. Seventy-five percent of patients were improved at 1 week.

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Year:  2009        PMID: 19590473     DOI: 10.1097/AJP.0b013e3181929877

Source DB:  PubMed          Journal:  Clin J Pain        ISSN: 0749-8047            Impact factor:   3.442


  5 in total

Review 1.  Evidence-based knee injections for the management of arthritis.

Authors:  Olivia T Cheng; Dmitri Souzdalnitski; Bruce Vrooman; Jianguo Cheng
Journal:  Pain Med       Date:  2012-05-23       Impact factor: 3.750

2.  Osteoarthritis pain has a significant neuropathic component: an exploratory in vivo patient model.

Authors:  Rui V Duarte; Jon H Raphael; Theodoros Dimitroulas; Elizabeth Sparkes; Jane L Southall; Robert L Ashford; George D Kitas
Journal:  Rheumatol Int       Date:  2013-11-10       Impact factor: 2.631

Review 3.  Use of Saline as a Placebo in Intra-articular Injections in Osteoarthritis: Potential Contributions to Nociceptive Pain Relief.

Authors:  David Bar-Or; Leonard T Rael; Edward N Brody
Journal:  Open Rheumatol J       Date:  2017-01-31

4.  The Effect of Subcutaneous and Intracutaneous Injections of Sterile Water and Normal Saline on Pain Intensity in Nulliparous Women: A Randomized Controlled Trial.

Authors:  Mehri Rezaie; Sanaz Shaabani; Farzin Sabouri Jahromi; Maryam Efafat Jahromi; Sheida Dakhesh
Journal:  Iran J Nurs Midwifery Res       Date:  2019 Sep-Oct

5.  Effects of intracutaneous injections of sterile water in patients with acute low back pain: a randomized, controlled, clinical trial.

Authors:  J Z Cui; Z S Geng; Y H Zhang; J Y Feng; P Zhu; X B Zhang
Journal:  Braz J Med Biol Res       Date:  2016-02-02       Impact factor: 2.590

  5 in total

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