BACKGROUND: There have been few studies of the clinical features of hypertrophic cardiomyopathy (HCM) in a community-based patient cohort in Japan. METHODS AND RESULTS: Cardiomyopathy registration was established in Kochi Prefecture and named the Kochi RYOMA (registry of myocardial diseases) study, consisting of 9 hospitals that registered 261 patients with a diagnosis of HCM. At registration, 74 patients (28%) had documented paroxysmal or chronic atrial fibrillation (AF). Although most patients (93%) were in New York Heart Association (NYHA) class I or II, 17 of the 18 patients in NYHA III had AF; 37 of the 74 patients with AF suffered from morbid events (embolism and/or heart failure (HF) admission), and 15 of 19 patients with embolic events had AF prior to or at the time of embolism. Of the 29 patients who had a history of HF admission, 8 had left ventricular systolic dysfunction, and the other 21 patients were hospitalized because of diastolic HF. AF occurred prior to HF in 20 of those 21 patients. Furthermore, 19 of those 20 patients with AF and diastolic HF were hospitalized within 1 year after detection of AF. CONCLUSIONS: In an unselected regional registry, AF was the major determinant of clinical deteriorations in patients with HCM.
BACKGROUND: There have been few studies of the clinical features of hypertrophic cardiomyopathy (HCM) in a community-based patient cohort in Japan. METHODS AND RESULTS:Cardiomyopathy registration was established in Kochi Prefecture and named the Kochi RYOMA (registry of myocardial diseases) study, consisting of 9 hospitals that registered 261 patients with a diagnosis of HCM. At registration, 74 patients (28%) had documented paroxysmal or chronic atrial fibrillation (AF). Although most patients (93%) were in New York Heart Association (NYHA) class I or II, 17 of the 18 patients in NYHA III had AF; 37 of the 74 patients with AF suffered from morbid events (embolism and/or heart failure (HF) admission), and 15 of 19 patients with embolic events had AF prior to or at the time of embolism. Of the 29 patients who had a history of HF admission, 8 had left ventricular systolic dysfunction, and the other 21 patients were hospitalized because of diastolic HF. AF occurred prior to HF in 20 of those 21 patients. Furthermore, 19 of those 20 patients with AF and diastolic HF were hospitalized within 1 year after detection of AF. CONCLUSIONS: In an unselected regional registry, AF was the major determinant of clinical deteriorations in patients with HCM.
Authors: Mariusz Klopotowski; Aleksandra Kwapiszewska; Krzysztof Kukula; Jacek Jamiolkowski; Maciej Dabrowski; Pawel Derejko; Artur Oreziak; Rafal Baranowski; Mateusz Spiewak; Magdalena Marczak; Anna Klisiewicz; Barbara Szepietowska; Zbigniew Chmielak; Adam Witkowski Journal: Clin Cardiol Date: 2018-10-16 Impact factor: 2.882
Authors: Oliver P Guttmann; Menelaos Pavlou; Constantinos O'Mahony; Lorenzo Monserrat; Aristides Anastasakis; Claudio Rapezzi; Elena Biagini; Juan Ramon Gimeno; Giuseppe Limongelli; Pablo Garcia-Pavia; William J McKenna; Rumana Z Omar; Perry M Elliott Journal: Eur J Heart Fail Date: 2015-07-16 Impact factor: 15.534
Authors: Konstantinos C Siontis; Jeffrey B Geske; Kevin Ong; Rick A Nishimura; Steve R Ommen; Bernard J Gersh Journal: J Am Heart Assoc Date: 2014-06-25 Impact factor: 5.501
Authors: Kyoung-Min Park; Sung Il Im; Eun Kyoung Kim; Sang-Chol Lee; Seung-Jung Park; June Soo Kim; Young Keun On Journal: PLoS One Date: 2016-06-03 Impact factor: 3.240