AIMS: Patients with isolated left ventricular non-compaction (IVNC) are at high risk for developing ventricular tachyarrhythmias. However, no analysis of invasive electrophysiological (EP) findings in these patients has yet been performed. METHODS AND RESULTS: We performed a retrospective analysis of EP findings in 24 patients with IVNC. Ventricular tachyarrhythmias were inducible in nine patients; of these, two patients had sustained monomorphic ventricular tachycardia (VT) and two patients had ventricular fibrillation. No specific electrocardiographic or echocardiographic finding was predictive of VT inducibility. Three of the 9 patients with inducible VT experienced ventricular tachyarrhythmias during the follow-up of 61.4+/-50 months, whereas no tachyarrhythmias or sudden deaths were noted in 12 patients without inducible VT during the follow-up of 30+/-19 months (3 patients in the latter group were lost to follow-up). Supraventricular tachyarrhythmias were inducible in seven patients. CONCLUSION: Our present study provides the first comprehensive analysis of EP findings in patients with IVNC. Ventricular and supraventricular arrhythmias can readily be induced in these patients, whereas the inducibility of a sustained monomorphic VT is relatively low. Further studies including long-term follow-up are required to investigate the role of EP testing for arrhythmic risk stratification in these patients.
AIMS: Patients with isolated left ventricular non-compaction (IVNC) are at high risk for developing ventricular tachyarrhythmias. However, no analysis of invasive electrophysiological (EP) findings in these patients has yet been performed. METHODS AND RESULTS: We performed a retrospective analysis of EP findings in 24 patients with IVNC. Ventricular tachyarrhythmias were inducible in nine patients; of these, two patients had sustained monomorphic ventricular tachycardia (VT) and two patients had ventricular fibrillation. No specific electrocardiographic or echocardiographic finding was predictive of VT inducibility. Three of the 9 patients with inducible VT experienced ventricular tachyarrhythmias during the follow-up of 61.4+/-50 months, whereas no tachyarrhythmias or sudden deaths were noted in 12 patients without inducible VT during the follow-up of 30+/-19 months (3 patients in the latter group were lost to follow-up). Supraventricular tachyarrhythmias were inducible in seven patients. CONCLUSION: Our present study provides the first comprehensive analysis of EP findings in patients with IVNC. Ventricular and supraventricular arrhythmias can readily be induced in these patients, whereas the inducibility of a sustained monomorphic VT is relatively low. Further studies including long-term follow-up are required to investigate the role of EP testing for arrhythmic risk stratification in these patients.
Authors: Jin Li; Jennifer Franke; Regina Pribe-Wolferts; Benjamin Meder; Philipp Ehlermann; Derliz Mereles; Florian Andre; Mohamed Assem Abdelrazek; Constanze Merten; Patrick A Schweizer; Rüdiger Becker; Hugo A Katus; Dierk Thomas Journal: Clin Res Cardiol Date: 2014-10-21 Impact factor: 5.460
Authors: George Bazoukis; Konstantinos Tyrovolas; Konstantinos P Letsas; Konstantinos Vlachos; Danny Radford; Cheuk To Chung; Tong Liu; Michael Efremidis; Gary Tse; Adrian Baranchuk Journal: Heart Fail Rev Date: 2022-07-01 Impact factor: 4.654
Authors: Francesca Romana Prandi; Federica Illuminato; Chiara Galluccio; Marialucia Milite; Massimiliano Macrini; Alessio Di Landro; Gaetano Idone; Marcello Chiocchi; Francesco Paolo Sbordone; Domenico Sergi; Francesco Romeo; Francesco Barillà Journal: Int J Environ Res Public Health Date: 2022-01-11 Impact factor: 3.390