| Literature DB >> 19589677 |
Yoshiyuki Sato1, Yu Onozaki, Tetsuya Sugimoto, Hideki Kurihara, Kaori Kamijo, Chie Kadowaki, Toshiaki Tsujino, Akiko Watanabe, Sachie Otsuki, Morihiro Mitsuya, Masato Iida, Kyosuke Haze, Takumitsu Machida, Yoko Nakatsuru, Hideya Komatani, Hidehito Kotani, Yoshikazu Iwasawa.
Abstract
A novel class of imidazopyridine derivatives was designed as PLK1 inhibitors. Extensive SAR studies supported by molecular modeling afforded a highly potent and selective compound 36. Compound 36 demonstrated good antitumor efficacy in xenograft nude rat model.Entities:
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Year: 2009 PMID： 19589677 DOI： 10.1016/j.bmcl.2009.06.084
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823