OBJECTIVE: To determine the effect of BDNF gene val66met polymorphism on serum BDNF levels in drug-free patients with major depressive disorder (MDD) and healthy subjects, that differ by gender. METHODS: Sixty-six drug-free patients (19 males+47 females) with non-psychotic MDD and fifty-six healthy controls (18 males+38 females) were recruited. Three-way ANOVA was employed to analyze the effect of mental health status, met-carriage and gender on Hamilton Depression Rating Scale (HDRS) scores and serum BDNF levels, by using the MIXED Procedure (SAS). RESULTS: Patients had a lower serum BDNF level than healthy subjects (22.47 vs. 27.49; p<0.0001). Met-carrier patients had a higher HDRS score than Val homozygote's (25.99 vs. 22.99, p<0.02). Serum BDNF level for met-carrier subjects (patients+controls) was lower than Val homozygote subjects (23.08 vs. 26.87; p<0.002). However, there were no effects of two-way interactions of met-carriage and mental health status on HDRS scores and serum BDNF levels. There was no gender effect on HDRS scores in the patients. Overall, male subjects (patients+controls) had a higher serum BDNF level than female subjects (26.87 vs. 23.08; p<0.002). However, there were no effects of two-way interactions of gender with mental health status and met-carriage on serum BDNF levels. CONCLUSIONS: We replicated the previous findings of lower serum BDNF levels during depression and in females. In addition, we found that met-carriage had an effect in reducing serum BDNF levels, regardless of gender and depression. Further animal and human studies with a larger sample size should investigate whether BDNF val66met polymorphism could alter brain and serum BDNF levels.
OBJECTIVE: To determine the effect of BDNF gene val66met polymorphism on serum BDNF levels in drug-free patients with major depressive disorder (MDD) and healthy subjects, that differ by gender. METHODS: Sixty-six drug-free patients (19 males+47 females) with non-psychotic MDD and fifty-six healthy controls (18 males+38 females) were recruited. Three-way ANOVA was employed to analyze the effect of mental health status, met-carriage and gender on Hamilton Depression Rating Scale (HDRS) scores and serum BDNF levels, by using the MIXED Procedure (SAS). RESULTS:Patients had a lower serum BDNF level than healthy subjects (22.47 vs. 27.49; p<0.0001). Met-carrier patients had a higher HDRS score than Val homozygote's (25.99 vs. 22.99, p<0.02). Serum BDNF level for met-carrier subjects (patients+controls) was lower than Val homozygote subjects (23.08 vs. 26.87; p<0.002). However, there were no effects of two-way interactions of met-carriage and mental health status on HDRS scores and serum BDNF levels. There was no gender effect on HDRS scores in the patients. Overall, male subjects (patients+controls) had a higher serum BDNF level than female subjects (26.87 vs. 23.08; p<0.002). However, there were no effects of two-way interactions of gender with mental health status and met-carriage on serum BDNF levels. CONCLUSIONS: We replicated the previous findings of lower serum BDNF levels during depression and in females. In addition, we found that met-carriage had an effect in reducing serum BDNF levels, regardless of gender and depression. Further animal and human studies with a larger sample size should investigate whether BDNFval66met polymorphism could alter brain and serum BDNF levels.
Authors: Antonio Terracciano; Maria Grazia Piras; Monia Lobina; Antonella Mulas; Osorio Meirelles; Angelina R Sutin; Wayne Chan; Serena Sanna; Manuela Uda; Laura Crisponi; David Schlessinger Journal: World J Biol Psychiatry Date: 2011-11-02 Impact factor: 4.132
Authors: A Terracciano; B Martin; D Ansari; T Tanaka; L Ferrucci; S Maudsley; M P Mattson; P T Costa Journal: Genes Brain Behav Date: 2010-03-22 Impact factor: 3.449
Authors: Josh D Woolley; Eric V Strobl; Wendy B Shelly; Anna M Karydas; R N Robin Ketelle; Owen M Wolkowitz; Bruce L Miller; Katherine P Rankin Journal: Curr Alzheimer Res Date: 2012-09 Impact factor: 3.498
Authors: Kirk I Erickson; Ruchika Shaurya Prakash; Michelle W Voss; Laura Chaddock; Susie Heo; Molly McLaren; Brandt D Pence; Stephen A Martin; Victoria J Vieira; Jeffrey A Woods; Edward McAuley; Arthur F Kramer Journal: J Neurosci Date: 2010-04-14 Impact factor: 6.167
Authors: M Mercedes Perez-Rodriguez; Antonia S New; Kim E Goldstein; Daniel Rosell; Qiaoping Yuan; Zhifeng Zhou; Colin Hodgkinson; David Goldman; Larry J Siever; Erin A Hazlett Journal: Psychiatry Res Neuroimaging Date: 2017-03-24 Impact factor: 2.376
Authors: Ripu D Jindal; Anil K Pillai; Sahebrao P Mahadik; Kevin Eklund; Debra M Montrose; Matcheri S Keshavan Journal: Schizophr Res Date: 2010-01-21 Impact factor: 4.939