Literature DB >> 1958713

Phenotypic transformation of normal rat kidney cells: a model for studying cellular alterations in oncogenesis.

E J van Zoelen1.   

Abstract

The growth characteristics of cells in culture change dramatically upon tumorigenic transformation. By the use of selective culture media supplemented with growth factor-inactivated serum, the changes in requirements for externally added polypeptide growth factors can readily be assessed. Certain nontumorigenic cell lines, including normal rat kidney (NRK) fibroblasts, can obtain the growth characteristics of a tumor cell when they became phenotypically transformed by addition of specific combinations of growth factors. This cell system provides a very attractive model for studying cellular alterations upon transformation, in particular for analyzing the molecular basis of density-dependent inhibition of growth (contact-inhibition).

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Year:  1991        PMID： 1958713

Source DB:  PubMed          Journal:  Crit Rev Oncog        ISSN： 0893-9675


  5 in total

1.  Epidermal growth factor receptor-induced activator protein 1 activity controls density-dependent growth inhibition in normal rat kidney fibroblasts.

Authors:  Jorrit J Hornberg; Henk Dekker; Peter H J Peters; Petra Langerak; Hans V Westerhoff; Jan Lankelma; Everardus J J van Zoelen
Journal:  Mol Biotechnol       Date:  2006-10       Impact factor: 2.695

2.  Production of autostimulatory growth factors by the human carcinoma line, RPMI 2650.

Authors:  B M Carey; M Dooley; R Weedle; M Clynes
Journal:  In Vitro Cell Dev Biol       Date:  1993-02

3.  Regulation of the efflux of putrescine and cadaverine from rapidly growing cultured RAW 264 cells by extracellular putrescine.

Authors:  R R Tjandrawinata; C V Byus
Journal:  Biochem J       Date:  1995-01-01       Impact factor: 3.857

4.  Prostaglandin F2 alpha induces unsynchronized intracellular calcium oscillations in monolayers of gap junctionally coupled NRK fibroblasts.

Authors:  Erik G A Harks; Wim J J M Scheenen; Peter H J Peters; Everardus J J van Zoelen; Alexander P R Theuvenet
Journal:  Pflugers Arch       Date:  2003-07-08       Impact factor: 3.657

5.  Bradykinin-induced growth inhibition of normal rat kidney (NRK) cells is paralleled by a decrease in epidermal-growth-factor receptor expression.

Authors:  E J Van Zoelen; P H Peters; G B Afink; S Van Genesen; D G De Roos; W Van Rotterdam; A P Theuvenet
Journal:  Biochem J       Date:  1994-03-01       Impact factor: 3.857
  5 in total

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