Literature DB >> 19586713

Ras activation contributes to the maintenance and expansion of Sca-1pos cells in a mouse model of breast cancer.

Ran-Ju Kim1, Soo-Rim Kim, Kyung-Jin Roh, Sang-Bum Park, Jeong-Ran Park, Kyung-Sun Kang, Gu Kong, Binwu Tang, Yu-An Yang, Ethan A Kohn, Lalage M Wakefield, Jeong-Seok Nam.   

Abstract

The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer and cause cancer metastasis and recurrence. In this study, we examined whether Ras signaling is associated with stemness of the CSCs population characterized by the stem cell antigen (Sca-1) phenotype in a 4T1 syngeneic mouse model of breast cancer. The Sca-1(pos) putative CSCs had high levels of activated Ras and phosphorylated MEK (p-MEK), compared with counterparts. The Ras farnesylation inhibitor (FTI-277) suppressed the maintenance and expansion of CSCs. Therefore, selective inhibition of Ras activation may be useful for stem-specific cancer therapy. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

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Year:  2009        PMID： 19586713      PMCID： PMC7291698          DOI： 10.1016/j.canlet.2009.06.010

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  45 in total

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4.  Prospective identification of tumorigenic breast cancer cells.

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Review 5.  Tumour stem cells and drug resistance.

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6.  A human colon cancer cell capable of initiating tumour growth in immunodeficient mice.

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  12 in total

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3.  ChIP-seq predicted estrogen receptor biding sites in human breast cancer cell line MCF7.

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4.  Association between tumorigenic potential and the fate of cancer cells in a syngeneic melanoma model.

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5.  Inhibitor of DNA-binding 4 contributes to the maintenance and expansion of cancer stem cells in 4T1 mouse mammary cancer cell line.

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Journal:  Lab Anim Res       Date:  2011-12-19

6.  Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB.

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8.  Genotoxic stress induces Sca-1-expressing metastatic mammary cancer cells.

Authors:  Jianlin Gong; Benjamin J Lang; Desheng Weng; Takanori Eguchi; Ayesha Murshid; Thiago J Borges; Sachin Doshi; Baizheng Song; Mary A Stevenson; Stuart K Calderwood
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9.  Doxorubicin-enriched, ALDH(br) mouse breast cancer stem cells are treatable to oncolytic herpes simplex virus type 1.

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