| Literature DB >> 19586051 |
Jia Chen1, Xiao-Hui Yan, Jia-Hong Dong, Peng Sang, Xin Fang, Ying-Tong Di, Zhong-Kai Zhang, Xiao-Jiang Hao.
Abstract
To investigate natural inhibitors against tobacco mosaic virus (TMV) from plants, 10 known beta-carboline alkaloids and one quassinoid have been isolated from MeOH extract of the wood of Picrasma quassioides Benn. These compounds were screened for their inhibitory activities against tobacco mosaic virus (TMV). The activity of each compound against TMV infection and replication was tested using a half-leaf assay method, a leaf-disk method, and Western blotting analyses. All of the beta-carboline alkaloids showed moderate anti-TMV activities and exhibited synergistic effects when combined with the quassinoid nigakilactone B (11). To our knowledge, this is the first report on anti-TMV activity of beta-carbolines and their synergistic effects against TMV when combined with a quassinoid.Entities:
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Year: 2009 PMID： 19586051 DOI： 10.1021/jf901632j
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279