| Literature DB >> 19586047 |
Henning J Jessen1, Damien Barbaras, Matthias Hamburger, Karl Gademann.
Abstract
An efficient synthesis of all four possible stereoisomers of the neurotrophic amide farinosone C was developed. The absolute and relative configuration was assigned by comparison of synthetic material with a derivatized authentic sample of the natural product. Several derivatives allowed for the generation of preliminary structure activity relationships concerning neurite outgrowth in PC-12 cells, unravelling L-tyrosinol-amide as the pharmacophore.Entities:
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Year: 2009 PMID： 19586047 DOI： 10.1021/ol901277q
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005