Literature DB >> 19585666

Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis.

Xi-Ping Zhang1, Han-Qing Chen, Fang Liu, Jie Zhang.   

Abstract

During the development and progression of severe acute pancreatitis (SAP), conspicuous immune dysregulation develops, which is mainly manifested as excessive immune response in the early stage and immunosuppression in the late stage. This process involves complex changes in a variety of immune molecules and cells, such as cytokines, complements, lymphocytes, and leukocytes. With the gradual deepening of studies on the development and progression of SAP, the role of immune dysregulation in the pathogenesis of SAP has attracted more and more attention. In this article, we review the advances in research on the immune dysregulation in SAP and the immunotherapy of this disease through exploring the formation of excessive immune response and immune suppression as well as their mutual transformation.

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Year:  2009        PMID： 19585666      PMCID： PMC2704966          DOI： 10.1631/jzus.B0820265

Source DB:  PubMed          Journal:  J Zhejiang Univ Sci B        ISSN： 1673-1581            Impact factor:   3.066


  33 in total

1.  Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis.

Authors:  Tao Ma; Chunsheng Kang; Hongwei Shao; Qinghui Qi; Wenquan Hu
Journal:  Eur Surg Res       Date:  2006-08-15       Impact factor: 1.745

Review 2.  New advances in acute pancreatitis.

Authors:  Matthew J DiMagno; Eugene P DiMagno
Journal:  Curr Opin Gastroenterol       Date:  2007-09       Impact factor: 3.287

Review 3.  Severe acute pancreatitis: Clinical course and management.

Authors:  Hans G Beger; Bettina M Rau
Journal:  World J Gastroenterol       Date:  2007-10-14       Impact factor: 5.742

Review 4.  Severe acute pancreatitis: pathogenetic aspects and prognostic factors.

Authors:  Ibrahim-A Al Mofleh
Journal:  World J Gastroenterol       Date:  2008-02-07       Impact factor: 5.742

5.  Decreased expression of Toll-like receptor 2 and 4 on macrophages in experimental severe acute pancreatitis.

Authors:  Naoki Matsumura; Yoshifumi Takeyama; Takashi Ueda; Takeo Yasuda; Makoto Shinzeki; Hidehiro Sawa; Takahiro Nakajima; Yoshikazu Kuroda
Journal:  Kobe J Med Sci       Date:  2007

Review 6.  Markers for predicting severity and progression of acute pancreatitis.

Authors:  Kerstin Schütte; Peter Malfertheiner
Journal:  Best Pract Res Clin Gastroenterol       Date:  2008       Impact factor: 3.043

7.  Thymosin alpha 1 improves severe acute pancreatitis in rats via regulation of peripheral T cell number and cytokine serum level.

Authors:  Weiyan Yao; Qi Zhu; Yaozong Yuan; Minmin Qiao; Yongping Zhang; Zukang Zhai
Journal:  J Gastroenterol Hepatol       Date:  2007-11       Impact factor: 4.029

8.  IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappa B activation.

Authors:  Takahito Hayashi; Yuko Ishida; Akihiko Kimura; Yoichiro Iwakura; Naofumi Mukaida; Toshikazu Kondo
Journal:  J Immunol       Date:  2007-06-01       Impact factor: 5.422

Review 9.  Acute pancreatitis.

Authors:  Jean-Louis Frossard; Michael L Steer; Catherine M Pastor
Journal:  Lancet       Date:  2008-01-12       Impact factor: 79.321

Review 10.  Role of tumor necrosis factor-alpha in acute pancreatitis: from biological basis to clinical evidence.

Authors:  Giuseppe Malleo; Emanuela Mazzon; Ajith K Siriwardena; Salvatore Cuzzocrea
Journal:  Shock       Date:  2007-08       Impact factor: 3.454
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  8 in total

1.  Effects of early enteral nutrition on immune function of severe acute pancreatitis patients.

Authors:  Jia-Kui Sun; Xin-Wei Mu; Wei-Qin Li; Zhi-Hui Tong; Jing Li; Shu-Yun Zheng
Journal:  World J Gastroenterol       Date:  2013-02-14       Impact factor: 5.742

Review 2.  Immunomodulatory therapies for acute pancreatitis.

Authors:  Jing Li; Wen-Juan Yang; Lu-Ming Huang; Cheng-Wei Tang
Journal:  World J Gastroenterol       Date:  2014-12-07       Impact factor: 5.742

3.  Clinical observation of immunity in patients with secondary infection from severe acute pancreatitis.

Authors:  YinFeng Shen; Nai-Qiang Cui
Journal:  Inflamm Res       Date:  2012-04-01       Impact factor: 4.575

4.  Clinical observation of immunity for severe acute pancreatitis.

Authors:  ZhiMin Liu; YinFeng Shen; NaiQiang Cui; Jing Yang
Journal:  Inflammation       Date:  2011-10       Impact factor: 4.092

5.  Immune dysregulation in patients with severe acute pancreatitis.

Authors:  YinFeng Shen; NaiQiang Cui; Bing Miao; ErPeng Zhao
Journal:  Inflammation       Date:  2011-02       Impact factor: 4.092

6.  Relationship between the degree of severe acute pancreatitis and patient immunity.

Authors:  Yinfeng Shen; Xiaochuan Deng; Nai Xu; Yan Li; Bin Miao; NaiQiang Cui
Journal:  Surg Today       Date:  2014-11-20       Impact factor: 2.549

7.  Dynamic Monitoring of Immunoinflammatory Response Identifies Immunoswitching Characteristics of Severe Acute Pancreatitis in Rats.

Authors:  Qian Zhuang; Liqiang Huang; Yue Zeng; Xu Wu; Gan Qiao; Minghua Liu; Lulu Wang; Yejiang Zhou; Yuxia Xiong
Journal:  Front Immunol       Date:  2022-05-19       Impact factor: 8.786

Review 8.  Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis.

Authors:  Lili Ding; Yimin Yang; Hongxiang Li; Haijiao Wang; Pujun Gao
Journal:  Front Cell Infect Microbiol       Date:  2020-03-31       Impact factor: 5.293
  8 in total

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