BACKGROUND: Apart from allergen avoidance and pharmacotreatment, specific immunotherapy (SIT) is the most important therapeutic option offered to allergic patients. Clinical efficacy of SIT depends on the specific allergen extract used, the quality and total cumulative amount of allergen applied and the treatment schedule of the therapy. In cluster SIT, 2-3 injections per treatment day are applied resulting in an accelerated achievement of the maintenance dose. PATIENTS AND METHODS: In this study 79 mite-sensitized adult allergic patients aged 18 to 59 years (mean 27.4+/-7.2 years) were investigated in terms of side-effects of cluster SIT during induction treatment. RESULTS: A total of 129 local hypersensitivity reactions (>grade 1) occurred or 10.2% of all injections (69% grade 1, 20% grade 2, 11% grade 3 and no grade 4 reactions). The total number of systemic reactions was 40 or 3.2% of all injections with 92% grade 1 and 8% grade 2 reactions. Grade 3 or 4 reactions did not occur. CONCLUSION: Cluster SIT with depot allergens represents an interesting alternative option to conventional dosage schedules of SIT.
BACKGROUND: Apart from allergen avoidance and pharmacotreatment, specific immunotherapy (SIT) is the most important therapeutic option offered to allergicpatients. Clinical efficacy of SIT depends on the specific allergen extract used, the quality and total cumulative amount of allergen applied and the treatment schedule of the therapy. In cluster SIT, 2-3 injections per treatment day are applied resulting in an accelerated achievement of the maintenance dose. PATIENTS AND METHODS: In this study 79 mite-sensitized adult allergicpatients aged 18 to 59 years (mean 27.4+/-7.2 years) were investigated in terms of side-effects of cluster SIT during induction treatment. RESULTS: A total of 129 local hypersensitivity reactions (>grade 1) occurred or 10.2% of all injections (69% grade 1, 20% grade 2, 11% grade 3 and no grade 4 reactions). The total number of systemic reactions was 40 or 3.2% of all injections with 92% grade 1 and 8% grade 2 reactions. Grade 3 or 4 reactions did not occur. CONCLUSION:Cluster SIT with depot allergens represents an interesting alternative option to conventional dosage schedules of SIT.
Authors: C Moreno; L Fernández-Távora; S Acero; M D Alonso; M J Barasona; R Blanco; A Cisteró; J Conde; J Fernández; S Fernández; M Fernández-Rivas; B E García; R García-Rodríguez; E Camacho; T González-Quevedo; A Gonzalo; P Guardia; M Sánchez-Cano; A I Tabar; F de la Torre Journal: J Investig Allergol Clin Immunol Date: 2003 Impact factor: 4.333
Authors: Ana Isabel Tabar; Susana Echechipía; Blanca Esther García; José María Olaguibel; Maria Teresa Lizaso; Belén Gómez; Maria Teresa Aldunate; Santiago Martin; Fernando Marcotegui Journal: J Allergy Clin Immunol Date: 2005-07 Impact factor: 10.793
Authors: S R Durham; S M Walker; E M Varga; M R Jacobson; F O'Brien; W Noble; S J Till; Q A Hamid; K T Nouri-Aria Journal: N Engl J Med Date: 1999-08-12 Impact factor: 91.245
Authors: A I Tabar; L Fernández-Távora; R Alonso; R Castillo; A Cisteró-Bahima; F de la Torre-Morin; J Fernández; B E García-Figueroa; S Fernández; J J García-González; J C García-Robaina; F Moreno; P Lobatón; I Sánchez-Machín; F de la Torre-Martínez Journal: J Investig Allergol Clin Immunol Date: 2004 Impact factor: 4.333