| Literature DB >> 19584571 |
Monica Rosa Loizzo1, Federica Menichini, Rosa Tundis, Marco Bonesi, Filomena Conforti, Farsad Nadjafi, Giancarlo Antonio Statti, Natale Giuseppe Frega, Francesco Menichini.
Abstract
In this study the chemical composition, cholinesterase inhibitory property and anti-inflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and alpha-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC(50) 2.26 microL/mL. Interesting cholinesterase inhibitory activity was also found with IC(50) values of 0.32 and 0.29 microL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC(50) value of 165 microg/mL. The absence of cytotoxicity at 1000 microg/mL was evaluated by MTT assay in 142BR cells.Entities:
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Year: 2009 PMID： 19584571 DOI： 10.5650/jos.58.443
Source DB: PubMed Journal: J Oleo Sci ISSN： 1345-8957 Impact factor: 1.601