Literature DB >> 1958450

The pharmacokinetics of oxycodone after intravenous injection in adults.

R Pöyhiä1, K T Olkkola, T Seppälä, E Kalso.   

Abstract

Oxycodone chloride (0.07 mg kg-1) was given by intravenous bolus to nine young adult surgical patients on the first postoperative day. Plasma was sampled for up to 12 h. Mean values of t1/2z, CL and Vss were 222 min, 0.78 l min-1 and 2.60 l kg-1, respectively. The concentrations of the metabolite noroxycodone was also measured. The mean AUC(0,12) ratio of noroxycodone to oxycodone was 0.33. Oxymorphone was not detected.

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Year:  1991        PMID： 1958450      PMCID： PMC1368617          DOI： 10.1111/j.1365-2125.1991.tb03942.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  6 in total

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