CONTEXT: The link between C-reactive protein (CRP) and adiposity deserves to be further explored, considering the controversial diabetogenic role of CRP. OBJECTIVE: We explored the potential causal role of CRP on measures of adiposity. DESIGN: We used a Mendelian randomization approach with the CRP and LEPR genes as instrumental variables in a cross-sectional Caucasian population-based study comprising 2526 men and 2836 women. Adiposity was measured using body mass index (BMI), fat and lean mass estimated by bioelectrical impedance, and waist circumference. RESULTS: Log-transformed CRP explained by the rs7553007 single-nucleotide polymorphism tagging the CRP gene was significantly associated with BMI [regression coefficient: 1.22 (0.18; 2.25), P = 0.02] and fat mass [2.67 (0.65; 4.68), P = 0.01] but not with lean mass in women, whereas no association was found in men. Log-transformed CRP explained by the rs1805096 LEPR single-nucleotide polymorphism was also positively associated, although not significantly, with BMI or fat mass. The combined CRP-LEPR instrument explained 2.24 and 0.77% of CRP variance in women and men, respectively. Log-transformed CRP explained by this combined instrument was significantly associated with BMI [0.98 (0.32; 1.63), P = 0.004], fat mass [2.07 (0.79; 3.34), P = 0.001], and waist [2.09 (0.39; 3.78), P = 0.01] in women but not men. CONCLUSION: Our data suggest that CRP is causally and positively related to BMI in women and that this is mainly due to fat mass. Results on the combined CRP-LEPR instrument suggest that leptin may play a role in the causal association between CRP and adiposity in women. Results in men were not significant.
CONTEXT: The link between C-reactive protein (CRP) and adiposity deserves to be further explored, considering the controversial diabetogenic role of CRP. OBJECTIVE: We explored the potential causal role of CRP on measures of adiposity. DESIGN: We used a Mendelian randomization approach with the CRP and LEPR genes as instrumental variables in a cross-sectional Caucasian population-based study comprising 2526 men and 2836 women. Adiposity was measured using body mass index (BMI), fat and lean mass estimated by bioelectrical impedance, and waist circumference. RESULTS: Log-transformed CRP explained by the rs7553007 single-nucleotide polymorphism tagging the CRP gene was significantly associated with BMI [regression coefficient: 1.22 (0.18; 2.25), P = 0.02] and fat mass [2.67 (0.65; 4.68), P = 0.01] but not with lean mass in women, whereas no association was found in men. Log-transformed CRP explained by the rs1805096LEPR single-nucleotide polymorphism was also positively associated, although not significantly, with BMI or fat mass. The combined CRP-LEPR instrument explained 2.24 and 0.77% of CRP variance in women and men, respectively. Log-transformed CRP explained by this combined instrument was significantly associated with BMI [0.98 (0.32; 1.63), P = 0.004], fat mass [2.07 (0.79; 3.34), P = 0.001], and waist [2.09 (0.39; 3.78), P = 0.01] in women but not men. CONCLUSION: Our data suggest that CRP is causally and positively related to BMI in women and that this is mainly due to fat mass. Results on the combined CRP-LEPR instrument suggest that leptin may play a role in the causal association between CRP and adiposity in women. Results in men were not significant.
Authors: Mika Kivimäki; Costan G Magnussen; Markus Juonala; Mika Kähönen; Johannes Kettunen; Britt-Marie Loo; Terho Lehtimäki; Jorma Viikari; Olli T Raitakari Journal: Int J Epidemiol Date: 2010-11-14 Impact factor: 7.196
Authors: Markus Juonala; Jonna Juhola; Costan G Magnussen; Peter Würtz; Jorma S A Viikari; Russell Thomson; Ilkka Seppälä; Jussi Hernesniemi; Mika Kähönen; Terho Lehtimäki; Mikko Hurme; Risto Telama; Vera Mikkilä; Carita Eklund; Leena Räsänen; Mirka Hintsanen; Liisa Keltikangas-Järvinen; Mika Kivimäki; Olli T Raitakari Journal: J Clin Endocrinol Metab Date: 2011-07-21 Impact factor: 5.958
Authors: Donna Spruijt-Metz; B Adar Emken; Mishala R Spruijt; Joyce M Richey; Laura J Berman; Britni R Belcher; Ya-Wen Hsu; Arianna D McClain; Christianne J Lane; Marc J Weigensberg Journal: Obesity (Silver Spring) Date: 2011-03-24 Impact factor: 5.002
Authors: Bertha L Bullen; Nicole M Jones; Claudia B Holzman; Yan Tian; Patricia K Senagore; Poul Thorsen; Kristin Skogstrand; David M Hougaard; Alla Sikorskii Journal: Reprod Sci Date: 2012-12-07 Impact factor: 3.060
Authors: Jacaline K Parkman; James Denvir; Xia Mao; Kristy D Dillon; Sofia Romero; Arnold M Saxton; Jung Han Kim Journal: Mamm Genome Date: 2017-10-05 Impact factor: 2.957