| Literature DB >> 19583948 |
Mathieu Ferron1, Gerard Karsenty.
Abstract
Though surgical removal of the stomach has long been linked to low bone mass, the molecular mechanism has been elusive. Amling and coworkers now demonstrate that gastric cell acid production is necessary for calcium absorption. Mice lacking this acidification develop hypocalcemia, with increased parathyroid hormone and osteoclast differentiation, and decreased bone mass.Entities:
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Year: 2009 PMID： 19583948 DOI： 10.1016/j.cmet.2009.06.004
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287