Literature DB >> 19583945

Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention.

Ronald C Wek1, Tracy G Anthony.   

Abstract

In this issue of Cell Metabolism, Kaufman and colleagues (Back et al., 2009) elegantly demonstrate that appropriate regulation of eIF2alpha phosphorylation improves glucose tolerance and beta cell viability by preventing the lethal buildup of oxidative damage due to unregulated synthesis, trafficking, and misfolding of proteins.

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Year:  2009        PMID: 19583945     DOI: 10.1016/j.cmet.2009.06.005

Source DB:  PubMed          Journal:  Cell Metab        ISSN: 1550-4131            Impact factor:   27.287


  5 in total

Review 1.  Regulation and function of elF2B in neurological and metabolic disorders.

Authors:  Filipe M Hanson; Rachel E Hodgson; Madalena I Ribeiro de Oliveira; K Elizabeth Allen; Susan Gerarda Campbell
Journal:  Biosci Rep       Date:  2022-06-30       Impact factor: 3.976

2.  Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation.

Authors:  Lakshmi Reddy Palam; Thomas D Baird; Ronald C Wek
Journal:  J Biol Chem       Date:  2011-02-01       Impact factor: 5.486

3.  Homeostasis and compensatory homeostasis: bridging Western medicine and traditional chinese medicine.

Authors:  Xiu-Juan Fan; Hao Yu; Jun Ren
Journal:  Curr Cardiol Rev       Date:  2011-02

4.  The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

Authors:  Brian F Teske; Sheree A Wek; Piyawan Bunpo; Judy K Cundiff; Jeanette N McClintick; Tracy G Anthony; Ronald C Wek
Journal:  Mol Biol Cell       Date:  2011-09-14       Impact factor: 4.138

5.  Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response.

Authors:  Ann E Collier; Ronald C Wek; Dan F Spandau
Journal:  J Invest Dermatol       Date:  2015-05-07       Impact factor: 8.551

  5 in total

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