M Yamamoto1, T Kuzuya, H Baba, K Yamada, T Nabeshima. 1. Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine 65, Showa-ku, Nagoya, Japan.
Abstract
OBJECTIVE: To describe the population pharmacokinetics of vancomycin in patients with gram-positive infections and to investigate the influence of type of infectious disease. METHODS: A two-compartment open model was adopted as a pharmacokinetic model. The nonlinear mixed-effects model was used to analyze the population pharmacokinetic models. RESULTS: We propose one general model and one infectious disease type-specific model. The general model showed that vancomycin clearance (CL) was linearly correlated with estimated creatinine clearance (CL(CR)) when CL(CR) was less than 85 mL/min, as expressed by CL(L/h) = 0.0322 x CL(CR) + 0.32. The distribution volumes of the central and peripheral compartment were different in healthy volunteers and patients with gram-positive infections. The infectious disease type-specific model showed that these differences were more pronounced in patients with pneumonia. CONCLUSION: The population pharmacokinetic parameters of vancomycin obtained here can be used to individualize the dosage of vancomycin in institutions with similar patient population characteristics.
OBJECTIVE: To describe the population pharmacokinetics of vancomycin in patients with gram-positive infections and to investigate the influence of type of infectious disease. METHODS: A two-compartment open model was adopted as a pharmacokinetic model. The nonlinear mixed-effects model was used to analyze the population pharmacokinetic models. RESULTS: We propose one general model and one infectious disease type-specific model. The general model showed that vancomycin clearance (CL) was linearly correlated with estimated creatinine clearance (CL(CR)) when CL(CR) was less than 85 mL/min, as expressed by CL(L/h) = 0.0322 x CL(CR) + 0.32. The distribution volumes of the central and peripheral compartment were different in healthy volunteers and patients with gram-positive infections. The infectious disease type-specific model showed that these differences were more pronounced in patients with pneumonia. CONCLUSION: The population pharmacokinetic parameters of vancomycin obtained here can be used to individualize the dosage of vancomycin in institutions with similar patient population characteristics.
Authors: Saeed A Alqahtani; Abdullah S Alsultan; Hussain M Alqattan; Ahmed Eldemerdash; Turki B Albacker Journal: Antimicrob Agents Chemother Date: 2018-06-26 Impact factor: 5.191
Authors: Pieter J Colin; Karel Allegaert; Alison H Thomson; Daan J Touw; Michael Dolton; Matthijs de Hoog; Jason A Roberts; Eyob D Adane; Masato Yamamoto; Dolores Santos-Buelga; Ana Martín-Suarez; Nicolas Simon; Fabio S Taccone; Yoke-Lin Lo; Emilia Barcia; Michel M R F Struys; Douglas J Eleveld Journal: Clin Pharmacokinet Date: 2019-06 Impact factor: 6.447
Authors: Ryan Marko; Julia Hajjar; Vanessa Nzeribe; Michelle Pittman; Vincent Deslandes; Nadia Sant; Juthaporn Cowan; Kwadwo Kyermentang; Tim Ramsay; Sheryl Zelenitsky; Salmaan Kanji Journal: Can J Hosp Pharm Date: 2021