Advances in image processing for autoradiography.

The next generation of techniques for image processing in autoradiography will extend the range for what is already a broad band method for functional mapping. Among the new tools under development are techniques to correct for tritium quenching. With these, high resolution, accurate 2-deoxyglucose mapping will be feasible. Also being developed are automatic segmentation algorithms which will permit rapid surveys of a large number of structures in a large number of brains. Together with recent refinements in other aspects of image processing of autoradiograms, these tools will provide both better quantification accuracy and faster analysis speed.