Literature DB >> 19582834

Porcine gelatin microsphere/calcium phosphate cement composites: an in vitro degradation study.

Wouter J E M Habraken1, Joop G C Wolke, Antonios G Mikos, John A Jansen.   

Abstract

Scaffolds for bone tissue engineering preferably should be mechanically stable, osteoconductive, biodegradable and porous. To comply with these characteristics, calcium phosphate cements (CPCs) with porcine (type A) gelatin microspheres were formulated. In this experiment, in vitro degradation of 10 wt % gelatin type A microsphere CPCs (GELA CPCs) was followed for 12 weeks in proteolytic medium. Results showed a gradual decrease in mass, compression strength and E-modulus. Morphology investigation showed that degradation of the spheres started at the surface of the composite and gradually proceeded to the inner part. Overall, porcine gelatin microspheres can be used to generate in situ macroporosity into an injectable CPC.

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Year:  2009        PMID： 19582834     DOI： 10.1002/jbm.b.31429

Source DB:  PubMed          Journal:  J Biomed Mater Res B Appl Biomater        ISSN： 1552-4973            Impact factor:   3.368


  7 in total

1.  Effect of the up-front heat treatment of gelatin particles dispersed in calcium phosphate cements on the in vivo material resorption and concomitant bone formation.

Authors:  Shoko Yamamoto; Yuta Matsushima; Yoshitaka Kanayama; Azusa Seki; Haruya Honda; Hidero Unuma; Yasuo Sakai
Journal:  J Mater Sci Mater Med       Date:  2017-02-07       Impact factor: 3.896

2.  Preparation and properties of calcium phosphate cements incorporated gelatin microspheres and calcium sulfate dihydrate as controlled local drug delivery system.

Authors:  Shu Cai; Yujia Zhai; Guohua Xu; Shanshan Lu; Wei Zhou; Xiaojian Ye
Journal:  J Mater Sci Mater Med       Date:  2011-09-06       Impact factor: 3.896

3.  Polymeric additives to enhance the functional properties of calcium phosphate cements.

Authors:  Roman A Perez; Hae-Won Kim; Maria-Pau Ginebra
Journal:  J Tissue Eng       Date:  2012-03-20       Impact factor: 7.813

4.  The Application of Microencapsulation Techniques in the Treatment of Endodontic and Periodontal Diseases.

Authors:  Asteria Luzardo Alvarez; Francisco Otero Espinar; José Blanco Méndez
Journal:  Pharmaceutics       Date:  2011-08-26       Impact factor: 6.321

5.  In vivo performance of novel soybean/gelatin-based bioactive and injectable hydroxyapatite foams.

Authors:  Anna Kovtun; Melanie J Goeckelmann; Antje A Niclas; Edgar B Montufar; Maria-Pau Ginebra; Josep A Planell; Matteo Santin; Anita Ignatius
Journal:  Acta Biomater       Date:  2014-10-29       Impact factor: 8.947

6.  Effects of Adding Polysaccharides and Citric Acid into Sodium Dihydrogen Phosphate Mixing Solution on the Material Properties of Gelatin-Hybridized Calcium-Phosphate Cement.

Authors:  Keishi Kiminami; Toshiisa Konishi; Minori Mizumoto; Kohei Nagata; Michiyo Honda; Hidetoshi Arimura; Mamoru Aizawa
Journal:  Materials (Basel)       Date:  2017-08-12       Impact factor: 3.623

7.  Efficacy of Octacalcium Phosphate and Octacalcium Phosphate/Gelatin Composite on the Repair of Critical-Sized Calvarial Defects in Rats.

Authors:  Fereydoon Sargolzaei Aval; Mohammad Reza Arab; Narjes Sargolzaei; Fateme Noushadi; Abdolsamad Eteghadi; Asadollah Keykhaei; Foroug Sargolzaei Aval; Azim Hedayat Pour
Journal:  J Dent (Tehran)       Date:  2018-03
  7 in total

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