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Literature DB >> 19582595

Role of human liver microsomes in in vitro metabolism of drugs-a review.

Abstract

Drug metabolism studies are essential and necessary during the evaluation of drugs. This review discusses the in vitro human liver models to estimate the drug metabolic fates in vivo. Different approaches are provided and emphasis is placed on the potential of human liver microsomes for drug metabolism and inhibition studies. The methodology for these studies using human liver microsomes, applications of human liver microsomes, and the drugs studied by human liver microsomes are listed. Human liver microsomes represent a critical experimental model for the evaluation of drug metabolites with a high probability of clinical success.

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Year: 2009 PMID： 19582595 DOI： 10.1007/s12010-009-8689-6

Source DB: PubMed Journal: Appl Biochem Biotechnol ISSN： 0273-2289 Impact factor: 2.926

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Cited

24 in total

1. Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides.

Authors: Shuaizhang Li; Jinghua Zhao; Ruili Huang; Michael F Santillo; Keith A Houck; Menghang Xia
Journal: Toxicol In Vitro Date: 2019-01-06 Impact factor: 3.500

2. Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions.

Authors: Xinwen Wang; Bing He; Jian Shi; Qian Li; Hao-Jie Zhu
Journal: Drug Metab Dispos Date: 2019-11-07 Impact factor: 3.922

3. In Vitro Metabolism and Hepatic Intrinsic Clearance of the Synthetic Cannabinoid Receptor Agonist JWH-122 and Its Four ω-Halogenated Analogues.

Authors: Anders Bork Davidsen; Marie Mardal; Kristian Linnet
Journal: AAPS J Date: 2019-05-15 Impact factor: 4.009

10. Cunninghamella as a microbiological model for metabolism of histamine H(3) receptor antagonist 1-[3-(4-tert-butylphenoxy)propyl]piperidine.

Authors: Elżbieta Pękala; Paulina Kubowicz; Dorota Łażewska
Journal: Appl Biochem Biotechnol Date: 2012-09-16 Impact factor: 2.926

Role of human liver microsomes in in vitro metabolism of drugs-a review.

1. Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides.

2. Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions.

3. In Vitro Metabolism and Hepatic Intrinsic Clearance of the Synthetic Cannabinoid Receptor Agonist JWH-122 and Its Four ω-Halogenated Analogues.

4. Role of CYP2A6 in Methimazole Bioactivation and Hepatotoxicity.

5. When Cofactors Aren't X Factors: Functional Groups That Are Labile in Human Liver Microsomes in the Absence of NADPH.

6. Dimensionally Enhanced Antibacterial Library Screening.

7. An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes.

8. In Vitro Biotransformation, Safety, and Chemopreventive Action of Novel 8-Methoxy-Purine-2,6-Dione Derivatives.

9. Characterization of Phase I Hepatic Metabolites of Anti-Premature Ejaculation Drug Dapoxetine by UHPLC-ESI-Q-TOF.

10. Cunninghamella as a microbiological model for metabolism of histamine H(3) receptor antagonist 1-[3-(4-tert-butylphenoxy)propyl]piperidine.