Actin in axons: stable scaffolds and dynamic filaments.

Actin filaments are thin polymers of the 42 kD protein actin. In mature axons a network of subaxolemmal actin filaments provide stability for membrane integrity and a substrate for short distance transport of cargos. In developing neurons dynamic regulation of actin polymerization and organization mediates axonal morphogenesis and axonal pathfinding to synaptic targets. Other changes in axonal shape, collateral branching, branch retraction, and axonal regeneration, also depend on actin filament dynamics. Actin filament organization is regulated by a diversity of actin-binding proteins (ABP). ABP are the focus of complex extrinsic and intrinsic signaling pathways, and many neurological pathologies and dysfunctions arise from defective regulation of ABP function.