Literature DB >> 19582205

Is the Y chromosome all that is required for sex determination?

A Karkanaki1, N Praras, I Katsikis, M Kita, D Panidis.   

Abstract

The gender identity of a person is the final result of genetic, hormonal and morphologic sex. Over a long period sex determination, and, specifically, male sex determination, has been correlated to the presence of the Y chromosome, which in turn has been the karyotype signal of the testes. However, research has provided data to convince that this theory is only part of the truth. In addition to the Y chromosome, a multitude of other genes influence sex determination and are able to cause male to female sex-reversal and vice versa. It is of great interest that these genes are located in more than one autosomal chromosomes or even in the X chromosome. It has become obvious that sex determination, according to the genetic sex, is a complicated matter that not only requires the presence of Y chromosome. This fact triggered extensive research of the Y chromosome and led to great insight into its structure, origin, evolution and eventual fate in humans.

Entities:  

Keywords:  chromosomes; gender identity; genes; sex determination; sex differentiation

Year:  2007        PMID: 19582205      PMCID: PMC2658794     

Source DB:  PubMed          Journal:  Hippokratia        ISSN: 1108-4189            Impact factor:   0.471


  38 in total

1.  A sex-chromosome anomaly in a case of gonadal dysgenesis (Turner's syndrome).

Authors:  C E FORD; K W JONES; P E POLANI; J C DE ALMEIDA; J H BRIGGS
Journal:  Lancet       Date:  1959-04-04       Impact factor: 79.321

2.  Four evolutionary strata on the human X chromosome.

Authors:  B T Lahn; D C Page
Journal:  Science       Date:  1999-10-29       Impact factor: 47.728

3.  Effects on gender identity of prenatal androgens and genital appearance: evidence from girls with congenital adrenal hyperplasia.

Authors:  Sheri A Berenbaum; J Michael Bailey
Journal:  J Clin Endocrinol Metab       Date:  2003-03       Impact factor: 5.958

4.  Testosterone formation and metabolism during male sexual differentiation in the human embryo.

Authors:  P K Siiteri; J D Wilson
Journal:  J Clin Endocrinol Metab       Date:  1974-01       Impact factor: 5.958

5.  Functional coherence of the human Y chromosome.

Authors:  B T Lahn; D C Page
Journal:  Science       Date:  1997-10-24       Impact factor: 47.728

6.  Conserved synteny between the chicken Z sex chromosome and human chromosome 9 includes the male regulatory gene DMRT1: a comparative (re)view on avian sex determination.

Authors:  I Nanda; E Zend-Ajusch; Z Shan; F Grützner; M Schartl; D W Burt; M Koehler; V M Fowler; G Goodwin; W J Schneider; S Mizuno; G Dechant; T Haaf; M Schmid
Journal:  Cytogenet Cell Genet       Date:  2000

7.  Analysis of the sex-determining region of the Y chromosome (SRY) in sex reversed patients: point-mutation in SRY causing sex-reversion in a 46,XY female.

Authors:  J Müller; M Schwartz; N E Skakkebaek
Journal:  J Clin Endocrinol Metab       Date:  1992-07       Impact factor: 5.958

8.  Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

Authors:  B K Jordan; M Mohammed; S T Ching; E Délot; X N Chen; P Dewing; A Swain; P N Rao; B R Elejalde; E Vilain
Journal:  Am J Hum Genet       Date:  2001-03-29       Impact factor: 11.025

9.  Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9.

Authors:  T Wagner; J Wirth; J Meyer; B Zabel; M Held; J Zimmer; J Pasantes; F D Bricarelli; J Keutel; E Hustert; U Wolf; N Tommerup; W Schempp; G Scherer
Journal:  Cell       Date:  1994-12-16       Impact factor: 41.582

10.  A male-specific role for SOX9 in vertebrate sex determination.

Authors:  J Kent; S C Wheatley; J E Andrews; A H Sinclair; P Koopman
Journal:  Development       Date:  1996-09       Impact factor: 6.868

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