Literature DB >> 19581963

Focal modulation microscopy.

Nanguang Chen1, Chee-Howe Wong, Colin J R Sheppard.   

Abstract

We report a novel light microscopy method for high resolution molecular imaging of thick biological tissues with one photon excited fluorescence. Effective optical sectioning and diffraction limited spatial resolution are achieved when imaging deep inside a multiple-scattering medium by the use of focal modulation, a technique for suppressing the background fluorescence signal excited by scattered light. Our method has been validated with animal tissue and an imaging depth around 600 microns has been demonstrated.

Mesh：

Year:  2008        PMID： 19581963     DOI： 10.1364/oe.16.018764

Source DB:  PubMed          Journal:  Opt Express        ISSN： 1094-4087            Impact factor:   3.894


  12 in total

1.  Enhancement of lateral resolution and optical sectioning capability of two-photon fluorescence microscopy by combining temporal-focusing with structured illumination.

Authors:  Keisuke Isobe; Takanori Takeda; Kyohei Mochizuki; Qiyuan Song; Akira Suda; Fumihiko Kannari; Hiroyuki Kawano; Akiko Kumagai; Atsushi Miyawaki; Katsumi Midorikawa
Journal:  Biomed Opt Express       Date:  2013-10-10       Impact factor: 3.732

2.  Implementation of spatial overlap modulation nonlinear optical microscopy using an electro-optic deflector.

Authors:  Keisuke Isobe; Hiroyuki Kawano; Akiko Kumagai; Atsushi Miyawaki; Katsumi Midorikawa
Journal:  Biomed Opt Express       Date:  2013-09-04       Impact factor: 3.732

3.  Modulated-alignment dual-axis (MAD) confocal microscopy for deep optical sectioning in tissues.

Authors:  Steven Y Leigh; Ye Chen; Jonathan T C Liu
Journal:  Biomed Opt Express       Date:  2014-04-30       Impact factor: 3.732

Review 4.  Optical Brain Imaging: A Powerful Tool for Neuroscience.

Authors:  Xinpei Zhu; Yanfang Xia; Xuecen Wang; Ke Si; Wei Gong
Journal:  Neurosci Bull       Date:  2016-08-17       Impact factor: 5.203

5.  Augmented line-scan focal modulation microscopy for multi-dimensional imaging of zebrafish heart in vivo.

Authors:  Shilpa Pant; Yubo Duan; Fei Xiong; Nanguang Chen
Journal:  Biomed Opt Express       Date:  2017-11-17       Impact factor: 3.732

6.  Contrast improvement in two-photon microscopy with instantaneous differential aberration imaging.

Authors:  Sheng Xiao; Jerome Mertz
Journal:  Biomed Opt Express       Date:  2019-04-17       Impact factor: 3.732

7.  Focal switching of photochromic fluorescent proteins enables multiphoton microscopy with superior image contrast.

Authors:  Ya-Ting Kao; Xinxin Zhu; Fang Xu; Wei Min
Journal:  Biomed Opt Express       Date:  2012-07-27       Impact factor: 3.732

8.  High-speed focal modulation microscopy using acousto-optical modulators.

Authors:  Shau Poh Chong; Chee Howe Wong; Kit Fei Wong; Colin J R Sheppard; Nanguang Chen
Journal:  Biomed Opt Express       Date:  2010-09-30       Impact factor: 3.732

9.  Stimulated emission reduced fluorescence microscopy: a concept for extending the fundamental depth limit of two-photon fluorescence imaging.

Authors:  Lu Wei; Zhixing Chen; Wei Min
Journal:  Biomed Opt Express       Date:  2012-05-22       Impact factor: 3.732

10.  Background-free deep imaging by spatial overlap modulation nonlinear optical microscopy.

Authors:  Keisuke Isobe; Hiroyuki Kawano; Takanori Takeda; Akira Suda; Akiko Kumagai; Hideaki Mizuno; Atsushi Miyawaki; Katsumi Midorikawa
Journal:  Biomed Opt Express       Date:  2012-06-14       Impact factor: 3.732
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