Literature DB >> 19581923

The role of caveolin-1 in prostate cancer: clinical implications.

T C Thompson1, S A Tahir, L Li, M Watanabe, K Naruishi, G Yang, D Kadmon, C J Logothetis, P Troncoso, C Ren, A Goltsov, S Park.   

Abstract

Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.

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Year:  2009        PMID： 19581923      PMCID： PMC2887695          DOI： 10.1038/pcan.2009.29

Source DB:  PubMed          Journal:  Prostate Cancer Prostatic Dis        ISSN： 1365-7852            Impact factor:   5.554


  66 in total

Review 1.  Role of plasmalemmal caveolae in signal transduction.

Authors:  P W Shaul; R G Anderson
Journal:  Am J Physiol       Date:  1998-11

2.  Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines.

Authors:  A F Hurlstone; G Reid; J R Reeves; J Fraser; G Strathdee; M Rahilly; E K Parkinson; D M Black
Journal:  Oncogene       Date:  1999-03-11       Impact factor: 9.867

3.  Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells.

Authors:  Y Nasu; T L Timme; G Yang; C H Bangma; L Li; C Ren; S H Park; M DeLeon; J Wang; T C Thompson
Journal:  Nat Med       Date:  1998-09       Impact factor: 53.440

4.  Expression of human fibroblast growth factor 2 mRNA is post-transcriptionally controlled by a unique destabilizing element present in the 3'-untranslated region between alternative polyadenylation sites.

Authors:  C Touriol; A Morillon; M C Gensac; H Prats; A C Prats
Journal:  J Biol Chem       Date:  1999-07-23       Impact factor: 5.157

5.  Elevated expression of caveolin is associated with prostate and breast cancer.

Authors:  G Yang; L D Truong; T L Timme; C Ren; T M Wheeler; S H Park; Y Nasu; C H Bangma; M W Kattan; P T Scardino; T C Thompson
Journal:  Clin Cancer Res       Date:  1998-08       Impact factor: 12.531

6.  Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers.

Authors:  J A Engelman; X L Zhang; M P Lisanti
Journal:  FEBS Lett       Date:  1998-10-09       Impact factor: 4.124

7.  Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line.

Authors:  Alicia Llorente; María C de Marco; Miguel A Alonso
Journal:  J Cell Sci       Date:  2004-10-05       Impact factor: 5.285

8.  Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer.

Authors:  T C Thompson; S H Park; T L Timme; C Ren; J A Eastham; L A Donehower; A Bradley; D Kadmon; G Yang
Journal:  Oncogene       Date:  1995-03-02       Impact factor: 9.867

9.  Genetic alterations in hormone-refractory recurrent prostate carcinomas.

Authors:  N N Nupponen; L Kakkola; P Koivisto; T Visakorpi
Journal:  Am J Pathol       Date:  1998-07       Impact factor: 4.307

10.  Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton.

Authors:  J R Glenney; L Zokas
Journal:  J Cell Biol       Date:  1989-06       Impact factor: 10.539
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  43 in total

1.  Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells.

Authors:  Preedakorn Chunhacha; Varisa Pongrakhananon; Yon Rojanasakul; Pithi Chanvorachote
Journal:  Am J Physiol Cell Physiol       Date:  2012-01-25       Impact factor: 4.249

2.  Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells.

Authors:  Vinata B Lokeshwar; Luis E Lopez; Daniel Munoz; Andrew Chi; Samir P Shirodkar; Soum D Lokeshwar; Diogo O Escudero; Neetika Dhir; Norman Altman
Journal:  Cancer Res       Date:  2010-03-23       Impact factor: 12.701

3.  Baseline and longitudinal plasma caveolin-1 level as a biomarker in active surveillance for early-stage prostate cancer.

Authors:  Spyridon P Basourakos; John W Davis; Brian F Chapin; John F Ward; Curtis A Pettaway; Louis L Pisters; Neema Navai; Mary F Achim; Xuemei Wang; Hsiang-Chun Chen; Seungtaek Choi; Deborah Kuban; Patricia Troncoso; Sam Hanash; Timothy C Thompson; Jeri Kim
Journal:  BJU Int       Date:  2017-08-16       Impact factor: 5.588

4.  Caveolin-1: an essential modulator of cancer cell radio-and chemoresistance.

Authors:  Stephanie Hehlgans; Nils Cordes
Journal:  Am J Cancer Res       Date:  2011-03-20       Impact factor: 6.166

5.  MMTV promoter-regulated caveolin-1 overexpression yields defective parenchymal epithelia in multiple exocrine organs of transgenic mice.

Authors:  Guang Yang; Sanghee Park; Guangwen Cao; Alexei Goltsov; Chengzhen Ren; Luan D Truong; Francesco Demayo; Timothy C Thompson
Journal:  Exp Mol Pathol       Date:  2010-04-22       Impact factor: 3.362

Review 6.  Caveolin-1, caveolae, and glioblastoma.

Authors:  Marie-Odile Parat; Gregory J Riggins
Journal:  Neuro Oncol       Date:  2012-04-16       Impact factor: 12.300

7.  Anti-caveolin-1 antibodies as anti-prostate cancer therapeutics.

Authors:  Shu-Ru Kuo; Salahaldin A Tahir; Sanghee Park; Timothy C Thompson; Scott Coffield; Arthur E Frankel; Jen-Sing Liu
Journal:  Hybridoma (Larchmt)       Date:  2012-04

8.  Pigment epithelium-derived factor inhibits caveolin-induced interleukin-8 gene expression and proliferation of human prostate cancer cells.

Authors:  Takanori Matsui; Ayako Ojima; Yuichiro Higashimoto; Junichi Taira; Kei Fukami; Sho-Ichi Yamagishi
Journal:  Oncol Lett       Date:  2015-08-04       Impact factor: 2.967

9.  Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition.

Authors:  Ahmed F Salem; Gloria Bonuccelli; Generoso Bevilacqua; Hwyda Arafat; Richard G Pestell; Federica Sotgia; Michael P Lisanti
Journal:  Cell Cycle       Date:  2011-11-01       Impact factor: 4.534

10.  Novel diagnostic biomarkers for prostate cancer.

Authors:  Chikezie O Madu; Yi Lu
Journal:  J Cancer       Date:  2010-10-06       Impact factor: 4.207
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