OBJECTIVE: To evaluate self-reported health-related quality of life, anxiety, depression, and cognitive function in pediatric septic shock survivors. DESIGN: A retrospective cohort study. SETTING: A 14-bed tertiary pediatric intensive care unit. PATIENTS: Children aged >or=8 yrs at the time of the follow-up who were admitted between 1995 and 2004 for septic shock. Inotropic and or vasoconstrictive agents were administered to these patients for >or=24 hrs. INTERVENTION: Health-related quality of life was assessed with the KIDSCREEN-52, anxiety with the State Trait Anxiety Inventory for Children, depression with the Children's Depression Inventory, and cognitive function with the cognitive scale of the TNO-AZL Children's Quality of Life Questionnaire Child Form. MEASUREMENTS AND MAIN RESULTS: Fifty of 82 eligible pediatric septic shock survivors were evaluated. The median age of the children at pediatric intensive care unit admission was 4.2 yrs (range, 0.0-17.0 yrs); the median age at follow-up was 10.7 yrs (range, 8.0-20.4 yrs). Health-related quality of life and anxiety scores were comparable to the age-related Dutch norm population. Depression scores were significantly better than the norm population, whereas cognitive function was significantly lower than the norm population. We found that 44% of the children had cognitive scores <25% of the norm population. Young age at the time of pediatric intensive care unit admission was predictive of cognitive problems, and cognitive problems were associated with lower emotional function. CONCLUSIONS: In this group of septic shock survivors, health-related quality of life, anxiety, and depression are equal to or slightly better than the age-related Dutch norm population. Cognitive function is decreased, especially in children admitted at younger ages. Follow-up studies with adequate neuropsychological testing are warranted to evaluate the association between septic shock, cognitive function, and risk factors for cognitive problems.
OBJECTIVE: To evaluate self-reported health-related quality of life, anxiety, depression, and cognitive function in pediatric septic shock survivors. DESIGN: A retrospective cohort study. SETTING: A 14-bed tertiary pediatric intensive care unit. PATIENTS: Children aged >or=8 yrs at the time of the follow-up who were admitted between 1995 and 2004 for septic shock. Inotropic and or vasoconstrictive agents were administered to these patients for >or=24 hrs. INTERVENTION: Health-related quality of life was assessed with the KIDSCREEN-52, anxiety with the State Trait Anxiety Inventory for Children, depression with the Children's Depression Inventory, and cognitive function with the cognitive scale of the TNO-AZL Children's Quality of Life Questionnaire Child Form. MEASUREMENTS AND MAIN RESULTS: Fifty of 82 eligible pediatric septic shock survivors were evaluated. The median age of the children at pediatric intensive care unit admission was 4.2 yrs (range, 0.0-17.0 yrs); the median age at follow-up was 10.7 yrs (range, 8.0-20.4 yrs). Health-related quality of life and anxiety scores were comparable to the age-related Dutch norm population. Depression scores were significantly better than the norm population, whereas cognitive function was significantly lower than the norm population. We found that 44% of the children had cognitive scores <25% of the norm population. Young age at the time of pediatric intensive care unit admission was predictive of cognitive problems, and cognitive problems were associated with lower emotional function. CONCLUSIONS: In this group of septic shock survivors, health-related quality of life, anxiety, and depression are equal to or slightly better than the age-related Dutch norm population. Cognitive function is decreased, especially in children admitted at younger ages. Follow-up studies with adequate neuropsychological testing are warranted to evaluate the association between septic shock, cognitive function, and risk factors for cognitive problems.
Authors: Allan C Calsavara; Frederico M Soriani; Leda Q Vieira; Priscila A Costa; Milene A Rachid; Antônio L Teixeira; Antônio L Teixiera Journal: Metab Brain Dis Date: 2014-08-23 Impact factor: 3.584
Authors: R Scott Watson; Sheri S Crow; Mary E Hartman; Jacques Lacroix; Folafoluwa O Odetola Journal: Pediatr Crit Care Med Date: 2017-03 Impact factor: 3.624
Authors: Mary K Sandquist; Mark S Clee; Smruti K Patel; Kelli A Howard; Toni Yunger; Usha D Nagaraj; Blaise V Jones; Lin Fei; Sudhakar Vadivelu; Hector R Wong Journal: Pediatr Crit Care Med Date: 2017-07 Impact factor: 3.624
Authors: Mary E Hartman; Mohammed J Saeed; Tellen Bennett; Katri Typpo; Renee Matos; Margaret A Olsen Journal: Pediatr Crit Care Med Date: 2017-03 Impact factor: 3.624
Authors: Mary E Hartman; Cydni N Williams; Trevor A Hall; Christopher C Bosworth; Juan A Piantino Journal: Pediatr Neurol Date: 2020-02-20 Impact factor: 3.372
Authors: Martha A Q Curley; R Scott Watson; Amy M Cassidy; Cheryl Burns; Rachel L Delinger; Derek C Angus; Lisa A Asaro; David Wypij; Sue R Beers Journal: Contemp Clin Trials Date: 2018-07-11 Impact factor: 2.226