OBJECTIVES: To investigate the efficacy and safety of oxaliplatin plus oral capecitabine (XELOX) as first-line chemotherapy in elderly patients with advanced gastric cancer (AGC). PATIENTS AND METHODS: Forty-four previously untreated patients with AGC aged 70 or older participated in the study. They received oxaliplatin 130 mg/m(2) as 2-hour intravenous infusion on day 1 and oral capecitabine 1000 mg/m(2) twice daily on days 1 to 14 every 3 weeks XELOX. RESULTS: All patients were assessable for toxicity and 41 patients for response. Median age was 75 years (range, 70-83). In total, 215 cycles of XELOX were delivered. The response rate according to Response Evaluation Criteria in Solid Tumors was 51.2% (95% confidence interval [CI]: 35.9%-66.5%), with 2 complete responses, 19 partial responses, 11 stable diseases, and 9 progressions. At 9.5 months median follow-up, median time to progression and overall survival were 5.6 (95% CI: 4.6-6.6) and 9.8 months (95% CI: 7.4-12.2), respectively. Toxicities were generally mild. Grades 3 to 4 adverse events included: neutropenia (6 patients, 13.6%), diarrhea (6 patients, 13.6%), thrombocytopenia (5 patients, 11.4%), hand-foot syndrome (4 patients, 9.1%), nausea and vomiting (2 patients, 4.5%), and anemia (1 patient, 2.3%). Neutropenic fever occurred in 2 patients. There was no treatment-related death. CONCLUSIONS: XELOX is active and well tolerated as first-line chemotherapy for elderly patients with AGC. Given its ease of administration, it represents a good therapeutic option in the elderly.
OBJECTIVES: To investigate the efficacy and safety of oxaliplatin plus oral capecitabine (XELOX) as first-line chemotherapy in elderly patients with advanced gastric cancer (AGC). PATIENTS AND METHODS: Forty-four previously untreated patients with AGC aged 70 or older participated in the study. They received oxaliplatin 130 mg/m(2) as 2-hour intravenous infusion on day 1 and oral capecitabine 1000 mg/m(2) twice daily on days 1 to 14 every 3 weeks XELOX. RESULTS: All patients were assessable for toxicity and 41 patients for response. Median age was 75 years (range, 70-83). In total, 215 cycles of XELOX were delivered. The response rate according to Response Evaluation Criteria in Solid Tumors was 51.2% (95% confidence interval [CI]: 35.9%-66.5%), with 2 complete responses, 19 partial responses, 11 stable diseases, and 9 progressions. At 9.5 months median follow-up, median time to progression and overall survival were 5.6 (95% CI: 4.6-6.6) and 9.8 months (95% CI: 7.4-12.2), respectively. Toxicities were generally mild. Grades 3 to 4 adverse events included: neutropenia (6 patients, 13.6%), diarrhea (6 patients, 13.6%), thrombocytopenia (5 patients, 11.4%), hand-foot syndrome (4 patients, 9.1%), nausea and vomiting (2 patients, 4.5%), and anemia (1 patient, 2.3%). Neutropenic fever occurred in 2 patients. There was no treatment-related death. CONCLUSIONS:XELOX is active and well tolerated as first-line chemotherapy for elderly patients with AGC. Given its ease of administration, it represents a good therapeutic option in the elderly.
Authors: Mohammad Ali Mashhadi; Zahra Sepehri; Ali Reza Bakhshipour; Ali Zivari; Hossein Ali Danesh; Hasan Ali Metanat; Azra Karimkoshteh; Seyed Mehdi Hashemi; Hossein Rahimi; Zohre Kiani Journal: Int J Hematol Oncol Stem Cell Res Date: 2016-10-01
Authors: Fernando Rivera; C Romero; P Jimenez-Fonseca; M Izquierdo-Manuel; A Salud; E Martínez; M Jorge; V Arrazubi; J C Méndez; P García-Alfonso; M Reboredo; J Barriuso; N Muñoz-Unceta; R Jimeno; C López Journal: Cancer Chemother Pharmacol Date: 2019-03-29 Impact factor: 3.333