Literature DB >> 19581086

The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.

Gillian E Lunniss1, Ashley A Barnes, Nick Barton, Matteo Biagetti, Federica Bianchi, Stephen M Blowers, Laura Caberlotto, Amanda Emmons, Ian P Holmes, Dino Montanari, Ros Norris, Dewi J Walters, Steve P Watson.   

Abstract

A novel small molecule NPY Y2 antagonist (3) identified from high throughput screening is described. A subsequent SAR study and optimisation programme based around this molecule is also described, leading to the identification of potent and soluble pyridyl analogue 36.

Mesh：

Substances：

Year:  2009        PMID： 19581086     DOI： 10.1016/j.bmcl.2009.06.035

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists.

Authors:  Gopi Kumar Mittapalli; Danielle Vellucci; Jun Yang; Marion Toussaint; Shaun P Brothers; Claes Wahlestedt; Edward Roberts
Journal:  Bioorg Med Chem Lett       Date:  2012-04-30       Impact factor: 2.823

Review 2.  PET Imaging of the Neuropeptide Y System: A Systematic Review.

Authors:  Inês C F Fonseca; Miguel Castelo-Branco; Cláudia Cavadas; Antero J Abrunhosa
Journal:  Molecules       Date:  2022-06-09       Impact factor: 4.927

Review 3.  Ligands of the neuropeptide Y Y2 receptor.

Authors:  Gopi Kumar Mittapalli; Edward Roberts
Journal:  Bioorg Med Chem Lett       Date:  2013-12-04       Impact factor: 2.823

Review 4.  Therapeutic potential of neuropeptide Y (NPY) receptor ligands.

Authors:  Shaun P Brothers; Claes Wahlestedt
Journal:  EMBO Mol Med       Date:  2010-11       Impact factor: 12.137

5.  Neuropeptide Y receptors: how to get subtype selectivity.

Authors:  Xavier Pedragosa-Badia; Jan Stichel; Annette G Beck-Sickinger
Journal:  Front Endocrinol (Lausanne)       Date:  2013-02-04       Impact factor: 5.555
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.