Literature DB >> 19580788

Small interfering RNA targeting CD81 ameliorated arthritis in rats.

Shuji Nakagawa1, Yuji Arai, Hiroki Mori, Yumi Matsushita, Toshikazu Kubo, Tohru Nakanishi.   

Abstract

CD81 belongs to a family of cell-surface protein (tetraspanin) known as one of the up-regulated elements in rheumatoid arthritis synoviocytes. In this study, the therapeutic effect of small interfering RNA targeting CD81 (siCD81) was examined by in vivo electroporation method. Treatment with siCD81 significantly ameliorated paw swelling of collagen-induced arthritic (CIA) rats. In histological examination, hypertrophy of synovium, bone erosion, and degeneration of articular cartilage were milder in rats treated with siCD81 than in the control group and the non-specific siRNA group. Expression of synoviolin, a rheumatoid regulator, was suppressed by siCD81. Thus, therapeutic intervention by targeting CD81 may be used in the treatment of rheumatoid arthritis.

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Year:  2009        PMID： 19580788     DOI： 10.1016/j.bbrc.2009.06.150

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Adenovirus-Mediated Small Interfering RNA Targeting TAK1 Ameliorates Joint Inflammation with Collagen-Induced Arthritis in Mice.

Authors:  Xinjing Luo; Yongfeng Chen; Guoju Lv; Zhidong Zhou; Jie Chen; Xuanrong Mo; Jiangwen Xie
Journal:  Inflammation       Date:  2017-06       Impact factor: 4.092

2.  Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments.

Authors:  Ashley M Trama; Zoie E Holzknecht; Anitra D Thomas; Kuei-Ying Su; Sean M Lee; Emily E Foltz; Sarah E Perkins; Shu S Lin; William Parker
Journal:  Cell Mol Immunol       Date:  2012-02-13       Impact factor: 11.530

Review 3.  siRNA-based therapeutic approaches for rheumatic diseases.

Authors:  Florence Apparailly; Christian Jorgensen
Journal:  Nat Rev Rheumatol       Date:  2012-10-23       Impact factor: 20.543

Review 4.  Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies.

Authors:  S Detchokul; E D Williams; M W Parker; A G Frauman
Journal:  Br J Pharmacol       Date:  2014-12       Impact factor: 8.739

5.  Long Non-Coding RNAs Target Pathogenetically Relevant Genes and Pathways in Rheumatoid Arthritis.

Authors:  Marzia Dolcino; Elisa Tinazzi; Antonio Puccetti; Claudio Lunardi
Journal:  Cells       Date:  2019-08-02       Impact factor: 6.600

6.  Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation.

Authors:  Kate E Broderick; Amy Chan; Feng Lin; Xuefei Shen; Gleb Kichaev; Amir S Khan; Justin Aubin; Tracy S Zimmermann; Niranjan Y Sardesai
Journal:  Mol Ther Nucleic Acids       Date:  2012-02-14       Impact factor: 10.183

7.  Transplantation of IL-1β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats.

Authors:  Shifeng Pan; Xuan Dong; Yan Wang; Tiansheng Zhou; Yuting Liu; An Zhou; Hua Xing
Journal:  Exp Ther Med       Date:  2021-12-14       Impact factor: 2.447
  7 in total

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