Investigation of the analgesic and antioxidant activity from an ethanol extract of seeds of Sesamum indicum.

The present study was intended to investigate the analgesic and antioxidant activity of ethanol extract of seeds of Sesamum indicum (Linn.) (family: Pedaliaceae). It was observed that the extract showed a significant inhibition on the writhing response produced by induction of acetic acid. The intensity of writhing inhibition of the extract was increased with the increase of dose. The extract produced about 48.19 and 75.46% writhing inhibition at the doses of 250 and 500 mg kg(-1), respectively, which was comparable to the standard drug ibuprofen where the inhibition was about 71.82% at the dose of 25 mg kg(-1). This study also intended to investigate the antioxidant property of the ethanolic extract of this sample. The ethanol extract showed 92.00% inhibition and 56.00% reduction ability in hydrogen donation and reducing power assays, respectively at maximum concentration of the extract tested. The antioxidant activity of the extract in all these in vitro assays was compared with standard antioxidant (ascorbic acid).