| Literature DB >> 19578993 |
Jang-Gi Choi1, Ok-Hwa Kang, Hee-Sung Chae, Brice Obiang-Obounou, Young-Seob Lee, You-Chang Oh, Min-San Kim, Dong-Won Shin, Jeong-Ah Kim, Young-Ho Kim, Dong-Yeul Kwon.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH(2)Cl(2), EtOAc, and H(2)O) were investigated against MRSA. The most active extract (CH(2)Cl(2)) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 microg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 microg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.Entities:
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Year: 2009 PMID： 19578993 DOI： 10.1007/s12010-009-8698-5
Source DB: PubMed Journal: Appl Biochem Biotechnol ISSN： 0273-2289 Impact factor: 2.926