BACKGROUND AND AIMS: Surgery is the only curative treatment for primary hyperparathyroidism. Focused surgical techniques are being practiced with increasing frequency. Preoperative imaging, such as scintigraphy, is a prerequisite for focused surgery. There is controversy about which preoperative imaging method should be used. The sensitivity reported for parathyroid scintigraphy varies considerably. This study was designed to determine the accuracy of the preoperative imaging routinely used at our institution. MATERIAL AND METHODS: This retrospective study included consecutive patients who underwent a routine dual-phase sestamibi-SPECT (single photon emission computed tomography) scintigraphy and subsequent operation with follow-up. Scintigraphy results were evaluated by comparing the results to surgical findings and histopathology. RESULTS: Two hundred and sixty-four individuals entered the study. Sensitivity for scintigraphy was 84%, specificity 91%, positive predictive value 91%, and negative predictive value 84%. CONCLUSIONS: Sestamibi-SPECT scintigraphy is a sensitive preoperative modality with high positive predictive value. Scintigraphy is a good indicator for when to perform a focused surgical approach and could often correctly guide the actual operation.
BACKGROUND AND AIMS: Surgery is the only curative treatment for primary hyperparathyroidism. Focused surgical techniques are being practiced with increasing frequency. Preoperative imaging, such as scintigraphy, is a prerequisite for focused surgery. There is controversy about which preoperative imaging method should be used. The sensitivity reported for parathyroid scintigraphy varies considerably. This study was designed to determine the accuracy of the preoperative imaging routinely used at our institution. MATERIAL AND METHODS: This retrospective study included consecutive patients who underwent a routine dual-phase sestamibi-SPECT (single photon emission computed tomography) scintigraphy and subsequent operation with follow-up. Scintigraphy results were evaluated by comparing the results to surgical findings and histopathology. RESULTS: Two hundred and sixty-four individuals entered the study. Sensitivity for scintigraphy was 84%, specificity 91%, positive predictive value 91%, and negative predictive value 84%. CONCLUSIONS: Sestamibi-SPECT scintigraphy is a sensitive preoperative modality with high positive predictive value. Scintigraphy is a good indicator for when to perform a focused surgical approach and could often correctly guide the actual operation.
Authors: John P Bilezikian; John T Potts; Ghada El-Hajj Fuleihan; Michael Kleerekoper; Robert Neer; Munro Peacock; Jonas Rastad; Shonni J Silverberg; Robert Udelsman; Samuel A Wells Journal: J Clin Endocrinol Metab Date: 2002-12 Impact factor: 5.958
Authors: S Aarum; J Nordenström; E Reihnér; J Zedenius; H Jacobsson; R Danielsson; M Bäckdahl; H Lindholm; G Wallin; B Hamberger; L O Farnebo Journal: Scand J Surg Date: 2007 Impact factor: 2.360
Authors: G Akbaba; D Berker; S Isik; Y Aydin; D Ciliz; I Peksoy; U Ozuguz; Y A Tutuncu; S Guler Journal: J Endocrinol Invest Date: 2011-05-27 Impact factor: 4.256
Authors: T H Vu; D Schellingerhout; N Guha-Thakurta; J Sun; W Wei; S C Kappadth; N Perrier; E E Kim; E Rohren; H H Chuang; F C Wong Journal: AJNR Am J Neuroradiol Date: 2018-12-06 Impact factor: 3.825