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Literature DB >> 19578812

Innate immunity: a key player in the mobilization of hematopoietic stem/progenitor cells.

Abstract

The mobilization of hematopoietic stem/progenitor cells (HSPCs) from bone marrow into peripheral blood (PB) is still not fully understood. Different chemokines, cytokines, growth factors, and neurotransmitters have been described that facilitate this process. However, mounting evidence suggests that mobilization of HSPCs is a part of the immune response and is mediated by innate immunity. We discuss evidence showing that complement system cleavage fragments play a crucial role in both the retention and mobilization of HSPCs by modulating their responsiveness to stromal-derived growth factor-1 (SDF-1) gradient (by C3-derived anaphylatoxins) and by modulating the release of granulocytes into PB that subsequently facilitate the egress of HSPCs (by C5-derived anaphylatoxins).

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Year: 2009 PMID： 19578812 DOI： 10.1007/s00005-009-0037-6

Source DB: PubMed Journal: Arch Immunol Ther Exp (Warsz) ISSN： 0004-069X Impact factor: 4.291

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Cited

18 in total

1. Complement C1q enhances homing-related responses of hematopoietic stem/progenitor cells.

Authors: Ali Jalili; Leah Marquez-Curtis; Neeta Shirvaikar; Marcin Wysoczynski; Mariusz Ratajczak; Anna Janowska-Wieczorek
Journal: Transfusion Date: 2010-09 Impact factor: 3.157

Review 2. A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients.

Authors: M Z Ratajczak; C H Kim; A Abdel-Latif; G Schneider; M Kucia; A J Morris; M J Laughlin; J Ratajczak
Journal: Leukemia Date: 2011-09-02 Impact factor: 11.528

3. 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals.

Authors: Jingjing Liu; Jiawei Zhao; Jen-Fu Lee; Allison Gartung; Hiba Jawadi; Wenliang Zhang; David Lominadze; Menq-Jer Lee
Journal: J Biochem Pharmacol Res Date: 2013-12

Review 4. The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes.

Authors: Leah A Marquez-Curtis; A Robert Turner; Santhi Sridharan; Mariusz Z Ratajczak; Anna Janowska-Wieczorek
Journal: Stem Cell Rev Rep Date: 2011-09 Impact factor: 5.739

5. Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells.

Authors: Ali Jalili; Neeta Shirvaikar; Leah Marquez-Curtis; Yuanyuan Qiu; Chris Korol; HakMo Lee; A Robert Turner; Mariusz Z Ratajczak; Anna Janowska-Wieczorek
Journal: Exp Hematol Date: 2010-02-12 Impact factor: 3.084

10. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes.

Authors: H M Lee; M Wysoczynski; R Liu; D-M Shin; M Kucia; M Botto; J Ratajczak; M Z Ratajczak
Journal: Leukemia Date: 2009-12-24 Impact factor: 11.528

Innate immunity: a key player in the mobilization of hematopoietic stem/progenitor cells.

1. Complement C1q enhances homing-related responses of hematopoietic stem/progenitor cells.

Review 2. A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients.

3. 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals.

Review 4. The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes.

5. Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells.

Review 6. The role of complement in the trafficking of hematopoietic stem/progenitor cells.

7. To stay or to leave: Stem cells and progenitor cells navigating the S1P gradient.

Review 8. The complement cascade as a mediator of tissue growth and regeneration.

Review 9. Innate immunity as orchestrator of bone marrow homing for hematopoietic stem/progenitor cells.

10. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes.