Literature DB >> 19578811

Immunomodulation by statins: mechanisms and potential impact on autoimmune diseases.

Sek C Chow1.   

Abstract

Statins are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) and they are the most effective agents for lowering cholesterol in clinical practice for the treatment of cardiovascular diseases. However, it has become clear that statins also have pleiotropic immunomodulatory effects in addition to their lipid-lowering properties. As a result, much attention has been focused on their potential as therapeutic agents for the treatment of inflammatory autoimmune diseases. In this review the effect of statins on the expression and function of a variety of immune-relevant molecules will be discussed alongside the underlying mechanisms that contribute to the immunomodulatory effects of statins.

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Year:  2009        PMID： 19578811     DOI： 10.1007/s00005-009-0038-5

Source DB:  PubMed          Journal:  Arch Immunol Ther Exp (Warsz)        ISSN： 0004-069X            Impact factor:   4.291


  12 in total

1.  Biomarker assessment of the immunomodulator effect of atorvastatin in stable renal transplant recipients and hypercholesterolemic patients.

Authors:  David Guillén; Federico Cofán; Emilio Ros; Olga Millán; Montse Cofán; Mercè Brunet
Journal:  Mol Diagn Ther       Date:  2010-12-01       Impact factor: 4.074

2.  Statins inhibit monocyte chemotactic protein 1 expression in endometriosis.

Authors:  Hakan Cakmak; Murat Basar; Yasemin Seval-Celik; Kevin G Osteen; Antoni J Duleba; Hugh S Taylor; Charles J Lockwood; Aydin Arici
Journal:  Reprod Sci       Date:  2012-01-19       Impact factor: 3.060

Review 3.  Is There Potential for Repurposing Statins as Novel Antimicrobials?

Authors:  Emma Hennessy; Claire Adams; F Jerry Reen; Fergal O'Gara
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191

4.  Statin use and risk of skin cancer.

Authors:  Brian M Lin; Wen-Qing Li; Eunyoung Cho; Gary C Curhan; Abrar A Qureshi
Journal:  J Am Acad Dermatol       Date:  2017-12-05       Impact factor: 11.527

5.  Clinical efficacy of subgingivally delivered simvastatin gel in chronic periodontitis patients.

Authors:  Swati Agarwal; Krishna Kumar Chaubey; Abhinav Chaubey; Vikas Agarwal; Ellora Madan; Manvi Chandra Agarwal
Journal:  J Indian Soc Periodontol       Date:  2016 Jul-Aug

6.  Statin Use and Influenza Vaccine Effectiveness in Persons >65 Years of Age, Taiwan.

Authors:  Lung-Wen Tsai; Yung-Tai Chen; Chia-Jen Shih; Shuo-Ming Ou; Pei-Wen Chao; Shih-Hsiu Lo
Journal:  Emerg Infect Dis       Date:  2020-06       Impact factor: 6.883

7.  Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties.

Authors:  Ning Zhao; Qian Dong; Cheng Qian; Sen Li; Qiong-Feng Wu; Dan Ding; Jing Li; Bin-Bin Wang; Ke-fang Guo; Jiang-jiao Xie; Xiang Cheng; Yu-Hua Liao; Yi-Mei Du
Journal:  Sci Rep       Date:  2015-11-30       Impact factor: 4.379

8.  The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics?

Authors:  Harpreet Singh Grover; Shailly Luthra; Shruti Maroo; Niteeka Maroo
Journal:  Dent Res J (Isfahan)       Date:  2013-03

9.  Exposure of Aspergillus fumigatus to Atorvastatin Leads to Altered Membrane Permeability and Induction of an Oxidative Stress Response.

Authors:  Ahmad Ajdidi; Gerard Sheehan; Kevin Kavanagh
Journal:  J Fungi (Basel)       Date:  2020-03-26

10.  The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.

Authors:  Esperanza Perucha; Rossella Melchiotti; Jack A Bibby; Wing Wu; Klaus Stensgaard Frederiksen; Ceri A Roberts; Zoe Hall; Gaelle LeFriec; Kevin A Robertson; Paul Lavender; Jens Gammeltoft Gerwien; Leonie S Taams; Julian L Griffin; Emanuele de Rinaldis; Lisa G M van Baarsen; Claudia Kemper; Peter Ghazal; Andrew P Cope
Journal:  Nat Commun       Date:  2019-01-30       Impact factor: 14.919
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