INTRODUCTION AND HYPOTHESIS: Urinary glycosaminoglycans (uGAG) have protective effects against urinary tract disorders. Here we investigated whether oral hormonal contraceptives (OC) affect uGAG excretion. METHODS: Urine specimens were from young women regularly taking: ethinyl estradiol + drospirenone, n = 9; ethinyl estradiol + cyproterone acetate, n = 9; and ethinyl estradiol + gestodene, n = 7. Controls were from ten women not taking OC. Total uGAG was assayed as hexuronic acid/urinary creatinine. Sulfated uGAG species was determined by electrophoresis. RESULTS: Unlike controls, total uGAG in the two halves of the menstrual cycle was similar in the OC groups. Whole cycle uGAG was higher in the OC groups (p < 0.01), especially for ethinyl estradiol + cyproterone acetate (p < 0.005). The three OC produced decreases of approximately 50% in heparan sulfate (p < 0.02) and dermatan sulfate (p < 0.02), and a approximately 100% increase in chondroitin sulfate (p < 0.004). CONCLUSIONS: uGAG excretion is changed in women taking OC, and this might enhance the protective effects of these molecules against urinary tract disorders.
INTRODUCTION AND HYPOTHESIS: Urinary glycosaminoglycans (uGAG) have protective effects against urinary tract disorders. Here we investigated whether oral hormonal contraceptives (OC) affect uGAG excretion. METHODS: Urine specimens were from young women regularly taking: ethinyl estradiol + drospirenone, n = 9; ethinyl estradiol + cyproterone acetate, n = 9; and ethinyl estradiol + gestodene, n = 7. Controls were from ten women not taking OC. Total uGAG was assayed as hexuronic acid/urinary creatinine. Sulfated uGAG species was determined by electrophoresis. RESULTS: Unlike controls, total uGAG in the two halves of the menstrual cycle was similar in the OC groups. Whole cycle uGAG was higher in the OC groups (p < 0.01), especially for ethinyl estradiol + cyproterone acetate (p < 0.005). The three OC produced decreases of approximately 50% in heparan sulfate (p < 0.02) and dermatan sulfate (p < 0.02), and a approximately 100% increase in chondroitin sulfate (p < 0.004). CONCLUSIONS: uGAG excretion is changed in women taking OC, and this might enhance the protective effects of these molecules against urinary tract disorders.
Authors: Paul J Hauser; Mikhail G Dozmorov; Barbara L Bane; Gennady Slobodov; Daniel J Culkin; Robert E Hurst Journal: J Urol Date: 2007-12-20 Impact factor: 7.450
Authors: Gennady Slobodov; Michael Feloney; Christopher Gran; Kimberly D Kyker; Robert E Hurst; Daniel J Culkin Journal: J Urol Date: 2004-04 Impact factor: 7.450
Authors: Gretchen M Lentz; Tamara Bavendam; Morton A Stenchever; Jane L Miller; Jackie Smalldridge Journal: Am J Obstet Gynecol Date: 2002-06 Impact factor: 8.661