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Literature DB >> 19578384

Conditional and reversible disruption of essential herpesvirus proteins.

Mandy Glass¹, Andreas Busche, Karen Wagner, Martin Messerle, Eva Maria Borst.

Abstract

Elucidating the function of essential proteins of complex pathogenic viruses is impeded by a paucity of complementing systems. By fusing a destabilizing domain of the FK506-binding protein to essential cytomegalovirus proteins, we generated virus mutants in which amounts of fusion proteins and viral growth can be regulated by the synthetic ligand shield-1. This conditional approach will greatly facilitate the analysis of gene functions of herpesviruses and viruses of other families.

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Year: 2009 PMID： 19578384 DOI： 10.1038/nmeth.1346

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

16 in total

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Authors: M Wagner; S Jonjic; U H Koszinowski; M Messerle
Journal: J Virol Date: 1999-08 Impact factor: 5.103

2. Dendritic cells under influence of mouse cytomegalovirus have a physiologic dual role: to initiate and to restrict T cell activation.

Authors: Sibylle Mathys; Timm Schroeder; Joachim Ellwart; Ulrich H Koszinowski; Martin Messerle; Ursula Just
Journal: J Infect Dis Date: 2003-03-06 Impact factor: 5.226

3. Cloning and mutagenesis of a herpesvirus genome as an infectious bacterial artificial chromosome.

Authors: M Messerle; I Crnkovic; W Hammerschmidt; H Ziegler; U H Koszinowski
Journal: Proc Natl Acad Sci U S A Date: 1997-12-23 Impact factor: 11.205

4. Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product.

Authors: G W Wilkinson; C Kelly; J H Sinclair; C Rickards
Journal: J Gen Virol Date: 1998-05 Impact factor: 3.891

5. A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation.

Authors: E S Mocarski; G W Kemble; J M Lyle; R F Greaves
Journal: Proc Natl Acad Sci U S A Date: 1996-10-15 Impact factor: 11.205

6. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.

Authors: Laura A Banaszynski; Ling-Chun Chen; Lystranne A Maynard-Smith; A G Lisa Ooi; Thomas J Wandless
Journal: Cell Date: 2006-09-08 Impact factor: 41.582

7. Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: a new approach for construction of HCMV mutants.

Authors: E M Borst; G Hahn; U H Koszinowski; M Messerle
Journal: J Virol Date: 1999-10 Impact factor: 5.103

Review 8. DNA viruses and viral proteins that interact with PML nuclear bodies.

Authors: R D Everett
Journal: Oncogene Date: 2001-10-29 Impact factor: 9.867

9. The essential human cytomegalovirus gene UL52 is required for cleavage-packaging of the viral genome.

Authors: Eva Maria Borst; Karen Wagner; Anne Binz; Beate Sodeik; Martin Messerle
Journal: J Virol Date: 2007-12-12 Impact factor: 5.103

10. Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.

Authors: Rebecca L Sanders; Charles L Clark; Christopher S Morello; Deborah H Spector
Journal: J Virol Date: 2008-05-07 Impact factor: 5.103

38 in total

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2. Human cytomegalovirus: bacterial artificial chromosome (BAC) cloning and genetic manipulation.

Authors: Anne M Paredes; Dong Yu
Journal: Curr Protoc Microbiol Date: 2012-02

3. Cytomegalovirus UL91 is essential for transcription of viral true late (γ2) genes.

Authors: Shinya Omoto; Edward S Mocarski
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4. The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates.

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5. Human cytomegalovirus early protein pUL21a promotes efficient viral DNA synthesis and the late accumulation of immediate-early transcripts.

Authors: Anthony R Fehr; Dong Yu
Journal: J Virol Date: 2010-11-03 Impact factor: 5.103

Review 6. Trial Watch-Oncolytic viruses and cancer therapy.

Authors: Jonathan Pol; Aitziber Buqué; Fernando Aranda; Norma Bloy; Isabelle Cremer; Alexander Eggermont; Philippe Erbs; Jitka Fucikova; Jérôme Galon; Jean-Marc Limacher; Xavier Preville; Catherine Sautès-Fridman; Radek Spisek; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal: Oncoimmunology Date: 2015-12-08 Impact factor: 8.110

10. Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis.

Authors: Zhikang Qian; Van Leung-Pineda; Baoqin Xuan; Helen Piwnica-Worms; Dong Yu
Journal: PLoS Pathog Date: 2010-03-19 Impact factor: 6.823