OBJECTIVES: The authors studied healthy UK Indian Asian and European white subjects to assess whether functional, structural and geometrical properties of the left heart are intrinsically related to ethnicity. BACKGROUND: Quantitative assessment of cardiac function and structure is necessary to diagnose heart failure syndromes and is validated to refine risk prediction. A better understanding of the demographic factors that influence these variables is required. METHODS: 458 healthy subjects were recruited from the London Life Sciences Prospective Population (LOLIPOP) study. They underwent 2-D and tissue Doppler echocardiography for quantification of left ventricular (LV) function, LV volumes, left atrial volume index (LAVI), left ventricular mass index (LVMI) and relative wall thickness (RWT). RESULTS: Indian Asians had attenuated mitral annular systolic velocity (8.9 cm/s vs 9.5 cm/s, p<0.001), lower mitral annular early diastolic velocity (10.3 cm/s vs 11.0 cm/s, p<0.001) and higher E/Ea ratio (7.9 vs 7.0, p<0.001) compared to European white subjects. Although Indian Asians had significantly smaller left heart volumes and LVMI, they had a significantly higher RWT (0.37 vs 0.35, p<0.001). After adjustment for covariates, these ethnicity-related differences remained highly significant (p<0.001). CONCLUSION: Compared to European white people, Indian Asians had attenuated longitudinal LV function, higher LV filling pressure and demonstrated a greater degree of concentric remodelling independent of other demographic and clinical parameters.
OBJECTIVES: The authors studied healthy UK Indian Asian and European white subjects to assess whether functional, structural and geometrical properties of the left heart are intrinsically related to ethnicity. BACKGROUND: Quantitative assessment of cardiac function and structure is necessary to diagnose heart failure syndromes and is validated to refine risk prediction. A better understanding of the demographic factors that influence these variables is required. METHODS: 458 healthy subjects were recruited from the London Life Sciences Prospective Population (LOLIPOP) study. They underwent 2-D and tissue Doppler echocardiography for quantification of left ventricular (LV) function, LV volumes, left atrial volume index (LAVI), left ventricular mass index (LVMI) and relative wall thickness (RWT). RESULTS: Indian Asians had attenuated mitral annular systolic velocity (8.9 cm/s vs 9.5 cm/s, p<0.001), lower mitral annular early diastolic velocity (10.3 cm/s vs 11.0 cm/s, p<0.001) and higher E/Ea ratio (7.9 vs 7.0, p<0.001) compared to European white subjects. Although Indian Asians had significantly smaller left heart volumes and LVMI, they had a significantly higher RWT (0.37 vs 0.35, p<0.001). After adjustment for covariates, these ethnicity-related differences remained highly significant (p<0.001). CONCLUSION: Compared to European white people, Indian Asians had attenuated longitudinal LV function, higher LV filling pressure and demonstrated a greater degree of concentric remodelling independent of other demographic and clinical parameters.
Authors: R Bathula; A D Hughes; R Panerai; J Potter; S A McG Thom; D P Francis; A C Shore; J Kooner; N Chaturvedi Journal: Diabetologia Date: 2010-06-12 Impact factor: 10.122
Authors: Jason Z Liu; Federica Tozzi; Dawn M Waterworth; Sreekumar G Pillai; Pierandrea Muglia; Lefkos Middleton; Wade Berrettini; Christopher W Knouff; Xin Yuan; Gérard Waeber; Peter Vollenweider; Martin Preisig; Nicholas J Wareham; Jing Hua Zhao; Ruth J F Loos; Inês Barroso; Kay-Tee Khaw; Scott Grundy; Philip Barter; Robert Mahley; Antero Kesaniemi; Ruth McPherson; John B Vincent; John Strauss; James L Kennedy; Anne Farmer; Peter McGuffin; Richard Day; Keith Matthews; Per Bakke; Amund Gulsvik; Susanne Lucae; Marcus Ising; Tanja Brueckl; Sonja Horstmann; H-Erich Wichmann; Rajesh Rawal; Norbert Dahmen; Claudia Lamina; Ozren Polasek; Lina Zgaga; Jennifer Huffman; Susan Campbell; Jaspal Kooner; John C Chambers; Mary Susan Burnett; Joseph M Devaney; Augusto D Pichard; Kenneth M Kent; Lowell Satler; Joseph M Lindsay; Ron Waksman; Stephen Epstein; James F Wilson; Sarah H Wild; Harry Campbell; Veronique Vitart; Muredach P Reilly; Mingyao Li; Liming Qu; Robert Wilensky; William Matthai; Hakon H Hakonarson; Daniel J Rader; Andre Franke; Michael Wittig; Arne Schäfer; Manuela Uda; Antonio Terracciano; Xiangjun Xiao; Fabio Busonero; Paul Scheet; David Schlessinger; David St Clair; Dan Rujescu; Gonçalo R Abecasis; Hans Jörgen Grabe; Alexander Teumer; Henry Völzke; Astrid Petersmann; Ulrich John; Igor Rudan; Caroline Hayward; Alan F Wright; Ivana Kolcic; Benjamin J Wright; John R Thompson; Anthony J Balmforth; Alistair S Hall; Nilesh J Samani; Carl A Anderson; Tariq Ahmad; Christopher G Mathew; Miles Parkes; Jack Satsangi; Mark Caulfield; Patricia B Munroe; Martin Farrall; Anna Dominiczak; Jane Worthington; Wendy Thomson; Steve Eyre; Anne Barton; Vincent Mooser; Clyde Francks; Jonathan Marchini Journal: Nat Genet Date: 2010-04-25 Impact factor: 38.330
Authors: Filip Zemrak; Bharath Ambale-Venkatesh; Gabriella Captur; Jonathan Chrispin; Ela Chamera; Mohammadali Habibi; Saman Nazarian; Saidi A Mohiddin; James C Moon; Steffen E Petersen; João A C Lima; David A Bluemke Journal: Circ Cardiovasc Imaging Date: 2017-02 Impact factor: 7.792